--- res: bibo_abstract: - 'Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic mechanisms and results into expression level equalization. Schistosoma mansoni has been previously described as a ZW species (i.e., female heterogamety, in opposition to XY male heterogametic species) with a partial dosage compensation, but underlying mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and epigenetic data (ChIP-Seq against H3K4me3, H3K27me3,andH4K20me1histonemarks) in free larval cercariae and intravertebrate parasitic stages. For the first time, we describe differences in dosage compensation status in ZW females, depending on the parasitic status: free cercariae display global dosage compensation, whereas intravertebrate stages show a partial dosage compensation. We also highlight regional differences of gene expression along the Z chromosome in cercariae, but not in the intravertebrate stages. Finally, we feature a consistent permissive chromatin landscape of the Z chromosome in both sexes and stages. We argue that dosage compensation in schistosomes is characterized by chromatin remodeling mechanisms in the Z-specific region.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Marion A L foaf_name: Picard, Marion A L foaf_surname: Picard foaf_workInfoHomepage: http://www.librecat.org/personId=2C921A7A-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8101-2518 - foaf_Person: foaf_givenName: Beatriz foaf_name: Vicoso, Beatriz foaf_surname: Vicoso foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4579-8306 - foaf_Person: foaf_givenName: David foaf_name: Roquis, David foaf_surname: Roquis - foaf_Person: foaf_givenName: Ingo foaf_name: Bulla, Ingo foaf_surname: Bulla - foaf_Person: foaf_givenName: Ronaldo C. foaf_name: Augusto, Ronaldo C. foaf_surname: Augusto - foaf_Person: foaf_givenName: Nathalie foaf_name: Arancibia, Nathalie foaf_surname: Arancibia - foaf_Person: foaf_givenName: Christoph foaf_name: Grunau, Christoph foaf_surname: Grunau - foaf_Person: foaf_givenName: Jérôme foaf_name: Boissier, Jérôme foaf_surname: Boissier - foaf_Person: foaf_givenName: Céline foaf_name: Cosseau, Céline foaf_surname: Cosseau bibo_doi: 10.1093/gbe/evz133 bibo_issue: '7' bibo_volume: 11 dct_date: 2019^xs_gYear dct_identifier: - UT:000484039500018 dct_isPartOf: - http://id.crossref.org/issn/1759-6653 dct_language: eng dct_publisher: Oxford Academic Press@ dct_title: 'Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome@' fabio_hasPubmedId: '31273378' ...