Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining gene tra-1

D. Zarkower, M. de Bono, R. Aronoff, J. Hodgkin, Developmental Genetics 15 (1994) 240–250.

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Journal Article | Published | English
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Abstract
The tra-1 gene is the terminal regulator in the sex determination pathway in C. elegans, directing all aspects of somatic sexual differentiation. Recessive loss-of-function (lf) mutations in tra-1 masculinize XX animals (normally somatically female), while dominant gain-of-function mutations feminize XO animals (normally male). Most tra-1 (lf) mutations can be fitted into a simple allelic series of somatic masculinization, but a small number of lf alleles do not fit into this series. Here we show that three of these mutations are associated with DNA rearrangements 5' to the coding region. One allele is an inversion that may be subject to a position effect. We also report the isolation of a new class of tra-1 alleles that are responsive to mutations in the smg system of RNA surveillance. We show that two of these express RNAs of aberrant size. We suggest that the smg-sensitive mutations may identify a carboxy-terminal domain required for negative regulation of tra-1 activity.
Publishing Year
Date Published
1994-01-13
Journal Title
Developmental Genetics
Volume
15
Issue
3
Page
240-250
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Zarkower D, de Bono M, Aronoff R, Hodgkin J. Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental Genetics. 1994;15(3):240-250. doi:10.1002/dvg.1020150306
Zarkower, D., de Bono, M., Aronoff, R., & Hodgkin, J. (1994). Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental Genetics, 15(3), 240–250. https://doi.org/10.1002/dvg.1020150306
Zarkower, David, Mario de Bono, Rachel Aronoff, and Jonathan Hodgkin. “Regulatory Rearrangements and Smg-Sensitive Allels of the C. Elegans Sex-Determining Gene Tra-1.” Developmental Genetics 15, no. 3 (1994): 240–50. https://doi.org/10.1002/dvg.1020150306.
D. Zarkower, M. de Bono, R. Aronoff, and J. Hodgkin, “Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining gene tra-1,” Developmental Genetics, vol. 15, no. 3, pp. 240–250, 1994.
Zarkower D, de Bono M, Aronoff R, Hodgkin J. 1994. Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental Genetics. 15(3), 240–250.
Zarkower, David, et al. “Regulatory Rearrangements and Smg-Sensitive Allels of the C. Elegans Sex-Determining Gene Tra-1.” Developmental Genetics, vol. 15, no. 3, Wiley, 1994, pp. 240–50, doi:10.1002/dvg.1020150306.

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