Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans

M. de Bono, C.I. Bargmann, Cell 94 (1998) 679–689.

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Journal Article | Published | English
Author
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Abstract
Natural isolates of C. elegans exhibit either solitary or social feeding behavior. Solitary foragers move slowly on a bacterial lawn and disperse across it, while social foragers move rapidly on bacteria and aggregate together. A loss-of-function mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor similar to neuropeptide Y receptors, causes a solitary strain to take on social behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild. One isoform, NPR-1 215F, is found exclusively in social strains, while the other isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene can induce solitary feeding behavior in a wild social strain. Thus, isoforms of a putative neuropeptide receptor generate natural variation in C. elegans feeding behavior.
Publishing Year
Date Published
1998-09-04
Journal Title
Cell
Volume
94
Issue
5
Page
679-689
ISSN
IST-REx-ID

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de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell. 1998;94(5):679-689. doi:10.1016/s0092-8674(00)81609-8
de Bono, M., & Bargmann, C. I. (1998). Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell, 94(5), 679–689. https://doi.org/10.1016/s0092-8674(00)81609-8
Bono, Mario de, and Cornelia I Bargmann. “Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.” Cell 94, no. 5 (1998): 679–89. https://doi.org/10.1016/s0092-8674(00)81609-8.
M. de Bono and C. I. Bargmann, “Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans,” Cell, vol. 94, no. 5, pp. 679–689, 1998.
de Bono M, Bargmann CI. 1998. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell. 94(5), 679–689.
de Bono, Mario, and Cornelia I. Bargmann. “Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.” Cell, vol. 94, no. 5, Elsevier, 1998, pp. 679–89, doi:10.1016/s0092-8674(00)81609-8.

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