Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli

M. de Bono, D.M. Tobin, M.W. Davis, L. Avery, C.I. Bargmann, Nature 419 (2002) 899–903.

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Journal Article | Published | English
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Abstract
Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation.
Publishing Year
Date Published
2002-10-31
Journal Title
Nature
Volume
419
Issue
6910
Page
899-903
ISSN
IST-REx-ID

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de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 2002;419(6910):899-903. doi:10.1038/nature01169
de Bono, M., Tobin, D. M., Davis, M. W., Avery, L., & Bargmann, C. I. (2002). Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature, 419(6910), 899–903. https://doi.org/10.1038/nature01169
Bono, Mario de, David M. Tobin, M. Wayne Davis, Leon Avery, and Cornelia I. Bargmann. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” Nature 419, no. 6910 (2002): 899–903. https://doi.org/10.1038/nature01169.
M. de Bono, D. M. Tobin, M. W. Davis, L. Avery, and C. I. Bargmann, “Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli,” Nature, vol. 419, no. 6910, pp. 899–903, 2002.
de Bono M, Tobin DM, Davis MW, Avery L, Bargmann CI. 2002. Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. Nature. 419(6910), 899–903.
de Bono, Mario, et al. “Social Feeding in Caenorhabditis Elegans Is Induced by Neurons That Detect Aversive Stimuli.” Nature, vol. 419, no. 6910, Springer Nature, 2002, pp. 899–903, doi:10.1038/nature01169.

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