--- res: bibo_abstract: - 'Social and solitary feeding in natural Caenorhabditis elegans isolates are associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1: social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V. Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18 and flp-21 genes as NPR-1 ligands and show that these peptides can differentially activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21 deletion partially phenocopied the npr-1(null) phenotype, which is consistent with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Candida foaf_name: Rogers, Candida foaf_surname: Rogers - foaf_Person: foaf_givenName: Vincenzina foaf_name: Reale, Vincenzina foaf_surname: Reale - foaf_Person: foaf_givenName: Kyuhyung foaf_name: Kim, Kyuhyung foaf_surname: Kim - foaf_Person: foaf_givenName: Heather foaf_name: Chatwin, Heather foaf_surname: Chatwin - foaf_Person: foaf_givenName: Chris foaf_name: Li, Chris foaf_surname: Li - foaf_Person: foaf_givenName: Peter foaf_name: Evans, Peter foaf_surname: Evans - foaf_Person: foaf_givenName: Mario foaf_name: de Bono, Mario foaf_surname: de Bono foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8347-0443 bibo_doi: 10.1038/nn1140 bibo_issue: '11' bibo_volume: 6 dct_date: 2003^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/1097-6256 - http://id.crossref.org/issn/1546-1726 dct_language: eng dct_publisher: Springer Nature@ dct_title: Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1@ fabio_hasPubmedId: '14555955' ...