Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1

C. Rogers, V. Reale, K. Kim, H. Chatwin, C. Li, P. Evans, M. de Bono, Nature Neuroscience 6 (2003) 1178–1185.

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Abstract
Social and solitary feeding in natural Caenorhabditis elegans isolates are associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1: social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V. Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18 and flp-21 genes as NPR-1 ligands and show that these peptides can differentially activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21 deletion partially phenocopied the npr-1(null) phenotype, which is consistent with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model in which solitary feeding evolved in an ancestral social strain of C. elegans by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and FLP-21 ligands.
Publishing Year
Date Published
2003-10-12
Journal Title
Nature Neuroscience
Volume
6
Issue
11
Page
1178-1185
IST-REx-ID

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Rogers C, Reale V, Kim K, et al. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience. 2003;6(11):1178-1185. doi:10.1038/nn1140
Rogers, C., Reale, V., Kim, K., Chatwin, H., Li, C., Evans, P., & de Bono, M. (2003). Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience, 6(11), 1178–1185. https://doi.org/10.1038/nn1140
Rogers, Candida, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris Li, Peter Evans, and Mario de Bono. “Inhibition of Caenorhabditis Elegans Social Feeding by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience 6, no. 11 (2003): 1178–85. https://doi.org/10.1038/nn1140.
C. Rogers et al., “Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1,” Nature Neuroscience, vol. 6, no. 11, pp. 1178–1185, 2003.
Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. 2003. Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience. 6(11), 1178–1185.
Rogers, Candida, et al. “Inhibition of Caenorhabditis Elegans Social Feeding by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience, vol. 6, no. 11, Springer Nature, 2003, pp. 1178–85, doi:10.1038/nn1140.

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