--- res: bibo_abstract: - Tonic receptors convey stimulus duration and intensity and are implicated in homeostatic control. However, how tonic homeostatic signals are generated and how they reconfigure neural circuits and modify animal behavior is poorly understood. Here we show that Caenorhabditis elegans O2-sensing neurons are tonic receptors that continuously signal ambient [O2] to set the animal's behavioral state. Sustained signaling relied on a Ca2+ relay involving L-type voltage-gated Ca2+ channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors. Tonic activity evoked continuous neuropeptide release, which helps elicit the enduring behavioral state associated with high [O2]. Sustained O2 receptor signaling was propagated to downstream neural circuits, including the hub interneuron RMG. O2 receptors evoked similar locomotory states at particular O2 concentrations, regardless of previous d[O2]/dt. However, a phasic component of the URX receptors' response to high d[O2]/dt, as well as tonic-to-phasic transformations in downstream interneurons, enabled transient reorientation movements shaped by d[O2]/dt. Our results highlight how tonic homeostatic signals can generate both transient and enduring behavioral change.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Karl Emanuel foaf_name: Busch, Karl Emanuel foaf_surname: Busch - foaf_Person: foaf_givenName: Patrick foaf_name: Laurent, Patrick foaf_surname: Laurent - foaf_Person: foaf_givenName: Zoltan foaf_name: Soltesz, Zoltan foaf_surname: Soltesz - foaf_Person: foaf_givenName: Robin Joseph foaf_name: Murphy, Robin Joseph foaf_surname: Murphy - foaf_Person: foaf_givenName: Olivier foaf_name: Faivre, Olivier foaf_surname: Faivre - foaf_Person: foaf_givenName: Berthold foaf_name: Hedwig, Berthold foaf_surname: Hedwig - foaf_Person: foaf_givenName: Martin foaf_name: Thomas, Martin foaf_surname: Thomas - foaf_Person: foaf_givenName: Heather L foaf_name: Smith, Heather L foaf_surname: Smith - foaf_Person: foaf_givenName: Mario foaf_name: de Bono, Mario foaf_surname: de Bono foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8347-0443 bibo_doi: 10.1038/nn.3061 bibo_issue: '4' bibo_volume: 15 dct_date: 2012^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/1097-6256 - http://id.crossref.org/issn/1546-1726 dct_language: eng dct_publisher: Springer Nature@ dct_title: Tonic signaling from O2 sensors sets neural circuit activity and behavioral state@ fabio_hasPubmedId: '22388961' ...