---
_id: '6135'
abstract:
- lang: eng
text: Many organisms have stress response pathways, components of which share homology
with players in complex human disease pathways. Research on stress response in
the nematode worm Caenorhabditis elegans has provided detailed insights into the
genetic and molecular mechanisms underlying complex human diseases. In this review
we focus on four different types of environmental stress responses – heat shock,
oxidative stress, hypoxia, and osmotic stress – and on how these can be used to
study the genetics of complex human diseases. All four types of responses involve
the genetic machineries that underlie a number of complex human diseases such
as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's.
We highlight the types of stress response experiments required to detect the genes
and pathways underlying human disease and suggest that studying stress biology
in worms can be translated to understanding human disease and provide potential
targets for drug discovery.
author:
- first_name: Miriam
full_name: Rodriguez, Miriam
last_name: Rodriguez
- first_name: L. Basten
full_name: Snoek, L. Basten
last_name: Snoek
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: Jan E.
full_name: Kammenga, Jan E.
last_name: Kammenga
citation:
ama: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. Worms under stress: C. elegans
stress response and its relevance to complex human disease and aging. Trends
in Genetics. 2013;29(6):367-374. doi:10.1016/j.tig.2013.01.010'
apa: 'Rodriguez, M., Snoek, L. B., de Bono, M., & Kammenga, J. E. (2013). Worms
under stress: C. elegans stress response and its relevance to complex human disease
and aging. Trends in Genetics. Elsevier. https://doi.org/10.1016/j.tig.2013.01.010'
chicago: 'Rodriguez, Miriam, L. Basten Snoek, Mario de Bono, and Jan E. Kammenga.
“Worms under Stress: C. Elegans Stress Response and Its Relevance to Complex Human
Disease and Aging.” Trends in Genetics. Elsevier, 2013. https://doi.org/10.1016/j.tig.2013.01.010.'
ieee: 'M. Rodriguez, L. B. Snoek, M. de Bono, and J. E. Kammenga, “Worms under stress:
C. elegans stress response and its relevance to complex human disease and aging,”
Trends in Genetics, vol. 29, no. 6. Elsevier, pp. 367–374, 2013.'
ista: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. 2013. Worms under stress:
C. elegans stress response and its relevance to complex human disease and aging.
Trends in Genetics. 29(6), 367–374.'
mla: 'Rodriguez, Miriam, et al. “Worms under Stress: C. Elegans Stress Response
and Its Relevance to Complex Human Disease and Aging.” Trends in Genetics,
vol. 29, no. 6, Elsevier, 2013, pp. 367–74, doi:10.1016/j.tig.2013.01.010.'
short: M. Rodriguez, L.B. Snoek, M. de Bono, J.E. Kammenga, Trends in Genetics 29
(2013) 367–374.
date_created: 2019-03-20T14:17:42Z
date_published: 2013-06-01T00:00:00Z
date_updated: 2021-01-12T08:06:17Z
day: '01'
doi: 10.1016/j.tig.2013.01.010
extern: '1'
intvolume: ' 29'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 367-374
publication: Trends in Genetics
publication_identifier:
issn:
- 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Worms under stress: C. elegans stress response and its relevance to complex
human disease and aging'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2013'
...