{"ddc":["570"],"issue":"50","doi":"10.1523/jneurosci.5368-13.2014","type":"journal_article","has_accepted_license":"1","page":"16726-16738","date_updated":"2021-01-12T08:06:14Z","oa_version":"Published Version","author":[{"full_name":"Gross, E.","first_name":"E.","last_name":"Gross"},{"full_name":"Soltesz, Z.","first_name":"Z.","last_name":"Soltesz"},{"last_name":"Oda","first_name":"S.","full_name":"Oda, S."},{"first_name":"V.","last_name":"Zelmanovich","full_name":"Zelmanovich, V."},{"full_name":"Abergel, Z.","first_name":"Z.","last_name":"Abergel"},{"id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"de Bono, Mario","last_name":"de Bono","orcid":"0000-0001-8347-0443","first_name":"Mario"}],"status":"public","external_id":{"pmid":["25505325"]},"publication_identifier":{"issn":["0270-6474","1529-2401"]},"year":"2014","month":"12","date_published":"2014-12-10T00:00:00Z","extern":"1","citation":{"ista":"Gross E, Soltesz Z, Oda S, Zelmanovich V, Abergel Z, de Bono M. 2014. GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings. Journal of Neuroscience. 34(50), 16726–16738.","apa":"Gross, E., Soltesz, Z., Oda, S., Zelmanovich, V., Abergel, Z., &#38; de Bono, M. (2014). GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/jneurosci.5368-13.2014\">https://doi.org/10.1523/jneurosci.5368-13.2014</a>","chicago":"Gross, E., Z. Soltesz, S. Oda, V. Zelmanovich, Z. Abergel, and Mario de Bono. “GLOBIN-5-Dependent O2 Responses Are Regulated by PDL-1/PrBP That Targets Prenylated Soluble Guanylate Cyclases to Dendritic Endings.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2014. <a href=\"https://doi.org/10.1523/jneurosci.5368-13.2014\">https://doi.org/10.1523/jneurosci.5368-13.2014</a>.","ieee":"E. Gross, Z. Soltesz, S. Oda, V. Zelmanovich, Z. Abergel, and M. de Bono, “GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings,” <i>Journal of Neuroscience</i>, vol. 34, no. 50. Society for Neuroscience, pp. 16726–16738, 2014.","ama":"Gross E, Soltesz Z, Oda S, Zelmanovich V, Abergel Z, de Bono M. GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings. <i>Journal of Neuroscience</i>. 2014;34(50):16726-16738. doi:<a href=\"https://doi.org/10.1523/jneurosci.5368-13.2014\">10.1523/jneurosci.5368-13.2014</a>","mla":"Gross, E., et al. “GLOBIN-5-Dependent O2 Responses Are Regulated by PDL-1/PrBP That Targets Prenylated Soluble Guanylate Cyclases to Dendritic Endings.” <i>Journal of Neuroscience</i>, vol. 34, no. 50, Society for Neuroscience, 2014, pp. 16726–38, doi:<a href=\"https://doi.org/10.1523/jneurosci.5368-13.2014\">10.1523/jneurosci.5368-13.2014</a>.","short":"E. Gross, Z. Soltesz, S. Oda, V. Zelmanovich, Z. Abergel, M. de Bono, Journal of Neuroscience 34 (2014) 16726–16738."},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"intvolume":"        34","quality_controlled":"1","title":"GLOBIN-5-dependent O2 responses are regulated by PDL-1/PrBP that targets prenylated soluble guanylate cyclases to dendritic endings","publication":"Journal of Neuroscience","language":[{"iso":"eng"}],"publication_status":"published","_id":"6126","oa":1,"abstract":[{"lang":"eng","text":"Aerobic animals constantly monitor and adapt to changes in O2 levels. The molecular mechanisms involved in sensing O2 are, however, incompletely understood. Previous studies showed that a hexacoordinated globin called GLB-5 tunes the dynamic range of O2-sensing neurons in natural C. elegans isolates, but is defective in the N2 lab reference strain (McGrath et al., 2009; Persson et al., 2009). GLB-5 enables a sharp behavioral switch when O2 changes between 21 and 17%. Here, we show that GLB-5 also confers rapid behavioral and cellular recovery from exposure to hypoxia. Hypoxia reconfigures O2-evoked Ca2+ responses in the URX O2 sensors, and GLB-5 enables rapid recovery of these responses upon re-oxygenation. Forward genetic screens indicate that GLB-5's effects on O2 sensing require PDL-1, the C. elegans ortholog of mammalian PrBP/PDE6δ protein. In mammals, PDE6δ regulates the traffic and activity of prenylated proteins (Zhang et al., 2004; Norton et al., 2005). PDL-1 promotes localization of GCY-33 and GCY-35, atypical soluble guanylate cyclases that act as O2 sensors, to the dendritic endings of URX and BAG neurons, where they colocalize with GLB-5. Both GCY-33 and GCY-35 are predicted to be prenylated. Dendritic localization is not essential for GCY-35 to function as an O2 sensor, but disrupting pdl-1 alters the URX neuron's O2 response properties. Functional GLB-5 can restore dendritic localization of GCY-33 in pdl-1 mutants, suggesting GCY-33 and GLB-5 are in a complex. Our data suggest GLB-5 and the soluble guanylate cyclases operate in close proximity to sculpt O2 responses."}],"volume":34,"file_date_updated":"2020-07-14T12:47:20Z","date_created":"2019-03-19T14:52:26Z","day":"10","publisher":"Society for Neuroscience","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"relation":"main_file","file_size":3263422,"access_level":"open_access","checksum":"a3dd71969f94c43909327cd083283d4b","date_created":"2019-03-19T14:55:58Z","content_type":"application/pdf","date_updated":"2020-07-14T12:47:20Z","file_id":"6127","creator":"kschuh","file_name":"2014_SFN_Gross.pdf"}],"pmid":1}