{"abstract":[{"lang":"eng","text":"Interleukin-17 (IL-17) is a major pro-inflammatory cytokine: it mediates responses to pathogens or tissue damage, and drives autoimmune diseases. Little is known about its role in the nervous system. Here we show that IL-17 has neuromodulator-like properties in Caenorhabditis elegans. IL-17 can act directly on neurons to alter their response properties and contribution to behaviour. Using unbiased genetic screens, we delineate an IL-17 signalling pathway and show that it acts in the RMG hub interneurons. Disrupting IL-17 signalling reduces RMG responsiveness to input from oxygen sensors, and renders sustained escape from 21% oxygen transient and contingent on additional stimuli. Over-activating IL-17 receptors abnormally heightens responses to 21% oxygen in RMG neurons and whole animals. IL-17 deficiency can be bypassed by optogenetic stimulation of RMG. Inducing IL-17 expression in adults can rescue mutant defects within 6 h. These findings reveal a non-immunological role of IL-17 modulating circuit function and behaviour."}],"quality_controlled":"1","pmid":1,"citation":{"apa":"Chen, C., Itakura, E., Nelson, G. M., Sheng, M., Laurent, P., Fenk, L. A., … de Bono, M. (2017). IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>","mla":"Chen, Changchun, et al. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>, vol. 542, no. 7639, Springer Nature, 2017, pp. 43–48, doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>.","ieee":"C. Chen <i>et al.</i>, “IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses,” <i>Nature</i>, vol. 542, no. 7639. Springer Nature, pp. 43–48, 2017.","chicago":"Chen, Changchun, Eisuke Itakura, Geoffrey M. Nelson, Ming Sheng, Patrick Laurent, Lorenz A. Fenk, Rebecca A. Butcher, Ramanujan S. Hegde, and Mario de Bono. “IL-17 Is a Neuromodulator of Caenorhabditis Elegans Sensory Responses.” <i>Nature</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/nature20818\">https://doi.org/10.1038/nature20818</a>.","ama":"Chen C, Itakura E, Nelson GM, et al. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. <i>Nature</i>. 2017;542(7639):43-48. doi:<a href=\"https://doi.org/10.1038/nature20818\">10.1038/nature20818</a>","short":"C. Chen, E. Itakura, G.M. Nelson, M. Sheng, P. Laurent, L.A. Fenk, R.A. Butcher, R.S. Hegde, M. de Bono, Nature 542 (2017) 43–48.","ista":"Chen C, Itakura E, Nelson GM, Sheng M, Laurent P, Fenk LA, Butcher RA, Hegde RS, de Bono M. 2017. IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature. 542(7639), 43–48."},"intvolume":"       542","author":[{"first_name":"Changchun","full_name":"Chen, Changchun","last_name":"Chen"},{"last_name":"Itakura","full_name":"Itakura, Eisuke","first_name":"Eisuke"},{"first_name":"Geoffrey M.","last_name":"Nelson","full_name":"Nelson, Geoffrey M."},{"first_name":"Ming","full_name":"Sheng, Ming","last_name":"Sheng"},{"full_name":"Laurent, Patrick","last_name":"Laurent","first_name":"Patrick"},{"first_name":"Lorenz A.","full_name":"Fenk, Lorenz A.","last_name":"Fenk"},{"first_name":"Rebecca A.","last_name":"Butcher","full_name":"Butcher, Rebecca A."},{"full_name":"Hegde, Ramanujan S.","last_name":"Hegde","first_name":"Ramanujan S."},{"full_name":"de Bono, Mario","last_name":"de Bono","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443"}],"status":"public","extern":"1","title":"IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses","date_published":"2017-02-02T00:00:00Z","oa_version":"Submitted Version","date_created":"2019-03-19T14:06:41Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0028-0836","1476-4687"]},"type":"journal_article","month":"02","publication":"Nature","_id":"6117","date_updated":"2021-01-12T08:06:12Z","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pubmed/28099418","open_access":"1"}],"page":"43-48","doi":"10.1038/nature20818","issue":"7639","external_id":{"pmid":["    28099418"]},"publication_status":"published","language":[{"iso":"eng"}],"oa":1,"day":"02","publisher":"Springer Nature","volume":542,"year":"2017"}