Memory of recent oxygen experience switches pheromone valence inCaenorhabditis elegans

L.A. Fenk, M. de Bono, Proceedings of the National Academy of Sciences 114 (2017) 4195–4200.

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Journal Article | Published | English
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Abstract
Animals adjust their behavioral priorities according to momentary needs and prior experience. We show that Caenorhabditis elegans changes how it processes sensory information according to the oxygen environment it experienced recently. C. elegans acclimated to 7% O2 are aroused by CO2 and repelled by pheromones that attract animals acclimated to 21% O2. This behavioral plasticity arises from prolonged activity differences in a circuit that continuously signals O2 levels. A sustained change in the activity of O2-sensing neurons reprograms the properties of their postsynaptic partners, the RMG hub interneurons. RMG is gap-junctionally coupled to the ASK and ADL pheromone sensors that respectively drive pheromone attraction and repulsion. Prior O2 experience has opposite effects on the pheromone responsiveness of these neurons. These circuit changes provide a physiological correlate of altered pheromone valence. Our results suggest C. elegans stores a memory of recent O2 experience in the RMG circuit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-dependent manner.
Publishing Year
Date Published
2017-04-18
Journal Title
Proceedings of the National Academy of Sciences
Volume
114
Issue
16
Page
4195-4200
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Fenk LA, de Bono M. Memory of recent oxygen experience switches pheromone valence inCaenorhabditis elegans. Proceedings of the National Academy of Sciences. 2017;114(16):4195-4200. doi:10.1073/pnas.1618934114
Fenk, L. A., & de Bono, M. (2017). Memory of recent oxygen experience switches pheromone valence inCaenorhabditis elegans. Proceedings of the National Academy of Sciences, 114(16), 4195–4200. https://doi.org/10.1073/pnas.1618934114
Fenk, Lorenz A., and Mario de Bono. “Memory of Recent Oxygen Experience Switches Pheromone Valence InCaenorhabditis Elegans.” Proceedings of the National Academy of Sciences 114, no. 16 (2017): 4195–4200. https://doi.org/10.1073/pnas.1618934114.
L. A. Fenk and M. de Bono, “Memory of recent oxygen experience switches pheromone valence inCaenorhabditis elegans,” Proceedings of the National Academy of Sciences, vol. 114, no. 16, pp. 4195–4200, 2017.
Fenk LA, de Bono M. 2017. Memory of recent oxygen experience switches pheromone valence inCaenorhabditis elegans. Proceedings of the National Academy of Sciences. 114(16), 4195–4200.
Fenk, Lorenz A., and Mario de Bono. “Memory of Recent Oxygen Experience Switches Pheromone Valence InCaenorhabditis Elegans.” Proceedings of the National Academy of Sciences, vol. 114, no. 16, National Academy of Sciences, 2017, pp. 4195–200, doi:10.1073/pnas.1618934114.
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