Structural basis of transcription initiation by RNA polymerase II

S. Sainsbury, C.A. Bernecky, P. Cramer, Nature Reviews Molecular Cell Biology 16 (2015) 129–143.

Download
No fulltext has been uploaded. References only!
Journal Article | Published | English
Author
; ;
Abstract
Transcription of eukaryotic protein-coding genes commences with the assembly of a conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general transcription factors, at promoter DNA. After two decades of research, the structural basis of transcription initiation is emerging. Crystal structures of many components of the initiation complex have been resolved, and structural information on Pol II complexes with general transcription factors has recently been obtained. Although mechanistic details await elucidation, available data outline how Pol II cooperates with the general transcription factors to bind to and open promoter DNA, and how Pol II directs RNA synthesis and escapes from the promoter.
Publishing Year
Date Published
2015-03-26
Journal Title
Nature Reviews Molecular Cell Biology
Volume
16
Issue
3
Page
129 - 143
IST-REx-ID

Cite this

Sainsbury S, Bernecky CA, Cramer P. Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 2015;16(3):129-143. doi:10.1038/nrm3952
Sainsbury, S., Bernecky, C. A., & Cramer, P. (2015). Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology, 16(3), 129–143. https://doi.org/10.1038/nrm3952
Sainsbury, Sarah, Carrie A Bernecky, and Patrick Cramer. “Structural Basis of Transcription Initiation by RNA Polymerase II.” Nature Reviews Molecular Cell Biology 16, no. 3 (2015): 129–43. https://doi.org/10.1038/nrm3952.
S. Sainsbury, C. A. Bernecky, and P. Cramer, “Structural basis of transcription initiation by RNA polymerase II,” Nature Reviews Molecular Cell Biology, vol. 16, no. 3, pp. 129–143, 2015.
Sainsbury S, Bernecky CA, Cramer P. 2015. Structural basis of transcription initiation by RNA polymerase II. Nature Reviews Molecular Cell Biology. 16(3), 129–143.
Sainsbury, Sarah, et al. “Structural Basis of Transcription Initiation by RNA Polymerase II.” Nature Reviews Molecular Cell Biology, vol. 16, no. 3, Nature Publishing Group, 2015, pp. 129–43, doi:10.1038/nrm3952.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar