Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling

N. Petridou, S. Grigolon, G. Salbreux, E. Hannezo, C.-P.J. Heisenberg, Nature Cell Biology 21 (2019) 169–178.

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Journal Article | Published | English
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Abstract
Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape and motion. The extent by which forces deform tissues critically depends on the rheological properties of the recipient tissue. Yet, whether and how dynamic changes in tissue rheology affect tissue morphogenesis and how they are regulated within the developing organism remain unclear. Here, we show that blastoderm spreading at the onset of zebrafish morphogenesis relies on a rapid, pronounced and spatially patterned tissue fluidization. Blastoderm fluidization is temporally controlled by mitotic cell rounding-dependent cell–cell contact disassembly during the last rounds of cell cleavages. Moreover, fluidization is spatially restricted to the central blastoderm by local activation of non-canonical Wnt signalling within the blastoderm margin, increasing cell cohesion and thereby counteracting the effect of mitotic rounding on contact disassembly. Overall, our results identify a fluidity transition mediated by loss of cell cohesion as a critical regulator of embryo morphogenesis.
Publishing Year
Date Published
2019-02-01
Journal Title
Nature Cell Biology
Acknowledged SSUs
Volume
21
Page
169–178
ISSN
IST-REx-ID

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Petridou N, Grigolon S, Salbreux G, Hannezo E, Heisenberg C-PJ. Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature Cell Biology. 2019;21:169–178. doi:10.1038/s41556-018-0247-4
Petridou, N., Grigolon, S., Salbreux, G., Hannezo, E., & Heisenberg, C.-P. J. (2019). Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature Cell Biology, 21, 169–178. https://doi.org/10.1038/s41556-018-0247-4
Petridou, Nicoletta, Silvia Grigolon, Guillaume Salbreux, Edouard Hannezo, and Carl-Philipp J Heisenberg. “Fluidization-Mediated Tissue Spreading by Mitotic Cell Rounding and Non-Canonical Wnt Signalling.” Nature Cell Biology 21 (2019): 169–178. https://doi.org/10.1038/s41556-018-0247-4.
N. Petridou, S. Grigolon, G. Salbreux, E. Hannezo, and C.-P. J. Heisenberg, “Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling,” Nature Cell Biology, vol. 21, pp. 169–178, 2019.
Petridou N, Grigolon S, Salbreux G, Hannezo E, Heisenberg C-PJ. 2019. Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling. Nature Cell Biology. 21, 169–178.
Petridou, Nicoletta, et al. “Fluidization-Mediated Tissue Spreading by Mitotic Cell Rounding and Non-Canonical Wnt Signalling.” Nature Cell Biology, vol. 21, Nature Publishing Group, 2019, pp. 169–178, doi:10.1038/s41556-018-0247-4.
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