--- res: bibo_abstract: - Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation. Here, we identify an unappreciated asset of platelets and show that adherent platelets use adhesion receptors to mechanically probe the adhesive substrate in their local microenvironment. When actomyosin-dependent traction forces overcome substrate resistance, platelets migrate and pile up the adhesive substrate together with any bound particulate material. They use this ability to act as cellular scavengers, scanning the vascular surface for potential invaders and collecting deposited bacteria. Microbe collection by migrating platelets boosts the activity of professional phagocytes, exacerbating inflammatory tissue injury in sepsis. This assigns platelets a central role in innate immune responses and identifies them as potential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infection. In addition to their role in thrombosis and hemostasis, platelets can also migrate to sites of infection to help trap bacteria and clear the vascular surface.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Florian R foaf_name: Gärtner, Florian R foaf_surname: Gärtner foaf_workInfoHomepage: http://www.librecat.org/personId=397A88EE-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6120-3723 - foaf_Person: foaf_givenName: Zerkah foaf_name: Ahmad, Zerkah foaf_surname: Ahmad - foaf_Person: foaf_givenName: Gerhild foaf_name: Rosenberger, Gerhild foaf_surname: Rosenberger - foaf_Person: foaf_givenName: Shuxia foaf_name: Fan, Shuxia foaf_surname: Fan - foaf_Person: foaf_givenName: Leo foaf_name: Nicolai, Leo foaf_surname: Nicolai - foaf_Person: foaf_givenName: Benjamin foaf_name: Busch, Benjamin foaf_surname: Busch - foaf_Person: foaf_givenName: Gökce foaf_name: Yavuz, Gökce foaf_surname: Yavuz - foaf_Person: foaf_givenName: Manja foaf_name: Luckner, Manja foaf_surname: Luckner - foaf_Person: foaf_givenName: Hellen foaf_name: Ishikawa Ankerhold, Hellen foaf_surname: Ishikawa Ankerhold - foaf_Person: foaf_givenName: Roman foaf_name: Hennel, Roman foaf_surname: Hennel - foaf_Person: foaf_givenName: Alexandre foaf_name: Benechet, Alexandre foaf_surname: Benechet - foaf_Person: foaf_givenName: Michael foaf_name: Lorenz, Michael foaf_surname: Lorenz - foaf_Person: foaf_givenName: Sue foaf_name: Chandraratne, Sue foaf_surname: Chandraratne - foaf_Person: foaf_givenName: Irene foaf_name: Schubert, Irene foaf_surname: Schubert - foaf_Person: foaf_givenName: Sebastian foaf_name: Helmer, Sebastian foaf_surname: Helmer - foaf_Person: foaf_givenName: Bianca foaf_name: Striednig, Bianca foaf_surname: Striednig - foaf_Person: foaf_givenName: Konstantin foaf_name: Stark, Konstantin foaf_surname: Stark - foaf_Person: foaf_givenName: Marek foaf_name: Janko, Marek foaf_surname: Janko - foaf_Person: foaf_givenName: Ralph foaf_name: Böttcher, Ralph foaf_surname: Böttcher - foaf_Person: foaf_givenName: Admar foaf_name: Verschoor, Admar foaf_surname: Verschoor - foaf_Person: foaf_givenName: Catherine foaf_name: Leon, Catherine foaf_surname: Leon - foaf_Person: foaf_givenName: Christian foaf_name: Gachet, Christian foaf_surname: Gachet - foaf_Person: foaf_givenName: Thomas foaf_name: Gudermann, Thomas foaf_surname: Gudermann - foaf_Person: foaf_givenName: Michael foaf_name: Mederos Y Schnitzler, Michael foaf_surname: Mederos Y Schnitzler - foaf_Person: foaf_givenName: Zachary foaf_name: Pincus, Zachary foaf_surname: Pincus - foaf_Person: foaf_givenName: Matteo foaf_name: Iannacone, Matteo foaf_surname: Iannacone - foaf_Person: foaf_givenName: Rainer foaf_name: Haas, Rainer foaf_surname: Haas - foaf_Person: foaf_givenName: Gerhard foaf_name: Wanner, Gerhard foaf_surname: Wanner - foaf_Person: foaf_givenName: Kirsten foaf_name: Lauber, Kirsten foaf_surname: Lauber - foaf_Person: foaf_givenName: Michael K foaf_name: Sixt, Michael K foaf_surname: Sixt foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-6620-9179 - foaf_Person: foaf_givenName: Steffen foaf_name: Massberg, Steffen foaf_surname: Massberg bibo_doi: 10.1016/j.cell.2017.11.001 bibo_issue: '6' bibo_volume: 171 dct_date: 2017^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/00928674 dct_language: eng dct_publisher: Cell Press@ dct_title: Migrating platelets are mechano scavengers that collect and bundle bacteria@ ...