{"volume":215,"file":[{"access_level":"open_access","creator":"dernst","relation":"main_file","file_size":1216437,"file_name":"2018_JournalExperMed_Reversat.pdf","date_updated":"2020-07-14T12:47:09Z","content_type":"application/pdf","checksum":"687beea1d64c213f4cb9e3c29ec11a14","date_created":"2019-02-06T08:49:52Z","file_id":"5931"}],"title":"IgM's exit route","date_created":"2018-12-16T22:59:18Z","quality_controlled":"1","oa_version":"Published Version","page":"2959-2961","article_processing_charge":"No","publication":"Journal of Experimental Medicine","department":[{"_id":"MiSi"}],"status":"public","publisher":"Rockefeller University Press","tmp":{"image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)"},"publication_identifier":{"issn":["00221007"]},"type":"journal_article","intvolume":"       215","author":[{"id":"35B76592-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0666-8928","last_name":"Reversat","full_name":"Reversat, Anne","first_name":"Anne"},{"full_name":"Sixt, Michael K","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"}],"doi":"10.1084/jem.20181934","has_accepted_license":"1","publication_status":"published","_id":"5672","ddc":["570"],"date_published":"2018-11-20T00:00:00Z","file_date_updated":"2020-07-14T12:47:09Z","year":"2018","oa":1,"scopus_import":"1","citation":{"mla":"Reversat, Anne, and Michael K. Sixt. “IgM’s Exit Route.” <i>Journal of Experimental Medicine</i>, vol. 215, no. 12, Rockefeller University Press, 2018, pp. 2959–61, doi:<a href=\"https://doi.org/10.1084/jem.20181934\">10.1084/jem.20181934</a>.","apa":"Reversat, A., &#38; Sixt, M. K. (2018). IgM’s exit route. <i>Journal of Experimental Medicine</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1084/jem.20181934\">https://doi.org/10.1084/jem.20181934</a>","ieee":"A. Reversat and M. K. Sixt, “IgM’s exit route,” <i>Journal of Experimental Medicine</i>, vol. 215, no. 12. Rockefeller University Press, pp. 2959–2961, 2018.","ista":"Reversat A, Sixt MK. 2018. IgM’s exit route. Journal of Experimental Medicine. 215(12), 2959–2961.","ama":"Reversat A, Sixt MK. IgM’s exit route. <i>Journal of Experimental Medicine</i>. 2018;215(12):2959-2961. doi:<a href=\"https://doi.org/10.1084/jem.20181934\">10.1084/jem.20181934</a>","short":"A. Reversat, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.","chicago":"Reversat, Anne, and Michael K Sixt. “IgM’s Exit Route.” <i>Journal of Experimental Medicine</i>. Rockefeller University Press, 2018. <a href=\"https://doi.org/10.1084/jem.20181934\">https://doi.org/10.1084/jem.20181934</a>."},"abstract":[{"text":"The release of IgM is the first line of an antibody response and precedes the generation of high affinity IgG in germinal centers. Once secreted by freshly activated plasmablasts, IgM is released into the efferent lymph of reactive lymph nodes as early as 3 d after immunization. As pentameric IgM has an enormous size of 1,000 kD, its diffusibility is low, and one might wonder how it can pass through the densely lymphocyte-packed environment of a lymph node parenchyma in order to reach its exit. In this issue of JEM, Thierry et al. show that, in order to reach the blood stream, IgM molecules take a specific micro-anatomical route via lymph node conduits.","lang":"eng"}],"month":"11","isi":1,"language":[{"iso":"eng"}],"external_id":{"isi":["000451920600002"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"12","date_updated":"2023-09-11T14:12:06Z","day":"20"}