IgM's exit route

A. Reversat, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.

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Journal Article | Published | English
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Abstract
The release of IgM is the first line of an antibody response and precedes the generation of high affinity IgG in germinal centers. Once secreted by freshly activated plasmablasts, IgM is released into the efferent lymph of reactive lymph nodes as early as 3 d after immunization. As pentameric IgM has an enormous size of 1,000 kD, its diffusibility is low, and one might wonder how it can pass through the densely lymphocyte-packed environment of a lymph node parenchyma in order to reach its exit. In this issue of JEM, Thierry et al. show that, in order to reach the blood stream, IgM molecules take a specific micro-anatomical route via lymph node conduits.
Publishing Year
Date Published
2018-11-20
Journal Title
Journal of Experimental Medicine
Volume
215
Issue
12
Page
2959-2961
ISSN
IST-REx-ID

Cite this

Reversat A, Sixt MK. IgM’s exit route. Journal of Experimental Medicine. 2018;215(12):2959-2961. doi:10.1084/jem.20181934
Reversat, A., & Sixt, M. K. (2018). IgM’s exit route. Journal of Experimental Medicine, 215(12), 2959–2961. https://doi.org/10.1084/jem.20181934
Reversat, Anne, and Michael K Sixt. “IgM’s Exit Route.” Journal of Experimental Medicine 215, no. 12 (2018): 2959–61. https://doi.org/10.1084/jem.20181934.
A. Reversat and M. K. Sixt, “IgM’s exit route,” Journal of Experimental Medicine, vol. 215, no. 12, pp. 2959–2961, 2018.
Reversat A, Sixt MK. 2018. IgM’s exit route. Journal of Experimental Medicine. 215(12), 2959–2961.
Reversat, Anne, and Michael K. Sixt. “IgM’s Exit Route.” Journal of Experimental Medicine, vol. 215, no. 12, Rockefeller University Press, 2018, pp. 2959–61, doi:10.1084/jem.20181934.
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