--- res: bibo_abstract: - The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters [1], whose polar subcellular localization determines the flow directionality. PIN-mediated auxin transport mediates the spatial and temporal activity of the auxin response machinery [2-7] that contributes to embryo patterning processes, including establishment of the apical (shoot) and basal (root) embryo poles [8]. However, little is known of upstream mechanisms guiding the (re)polarization of auxin fluxes during embryogenesis [9]. Here, we developed a model of plant embryogenesis that correctly generates emergent cell polarities and auxin-mediated sequential initiation of apical-basal axis of plant embryo. The model relies on two precisely localized auxin sources and a feedback between auxin and the polar, subcellular PIN transporter localization. Simulations reproduced PIN polarity and auxin distribution, as well as previously unknown polarization events during early embryogenesis. The spectrum of validated model predictions suggests that our model corresponds to a minimal mechanistic framework for initiation and orientation of the apical-basal axis to guide both embryonic and postembryonic plant development.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Krzysztof T foaf_name: Wabnik, Krzysztof T foaf_surname: Wabnik foaf_workInfoHomepage: http://www.librecat.org/personId=4DE369A4-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-7263-0560 - foaf_Person: foaf_givenName: Hélène foaf_name: Robert, Hélène foaf_surname: Robert - foaf_Person: foaf_givenName: Richard foaf_name: Smith, Richard foaf_surname: Smith - foaf_Person: foaf_givenName: Jirí foaf_name: Friml, Jirí foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 bibo_doi: 10.1016/j.cub.2013.10.038 bibo_issue: '24' bibo_volume: 23 dct_date: 2013^xs_gYear dct_language: eng dct_publisher: Cell Press@ dct_title: Modeling framework for the establishment of the apical-basal embryonic axis in plants@ ...