{"date_published":"2015-06-15T00:00:00Z","author":[{"first_name":"Katrin","last_name":"Holst","full_name":"Holst, Katrin"},{"full_name":"Guseva, Daria","last_name":"Guseva","first_name":"Daria"},{"full_name":"Schindler, Susann","last_name":"Schindler","first_name":"Susann"},{"orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K"},{"full_name":"Braun, Armin","last_name":"Braun","first_name":"Armin"},{"first_name":"Himpriya","full_name":"Chopra, Himpriya","last_name":"Chopra"},{"first_name":"Oliver","last_name":"Pabst","full_name":"Pabst, Oliver"},{"first_name":"Evgeni","full_name":"Ponimaskin, Evgeni","last_name":"Ponimaskin"}],"status":"public","year":"2015","day":"15","type":"journal_article","publication":"Journal of Cell Science","date_created":"2018-12-11T11:46:41Z","volume":128,"date_updated":"2021-01-12T08:00:54Z","page":"2866 - 2880","month":"06","_id":"477","quality_controlled":"1","title":"The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells","department":[{"_id":"MiSi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"       128","publist_id":"7343","publisher":"Company of Biologists","abstract":[{"text":"Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate adaptive immune responses upon inflammation. Inflammatory processes are often associated with an increased production of serotonin, which operates by activating specific receptors. However, the functional role of serotonin receptors in regulation of dendritic cell functions is poorly understood. Here, we demonstrate that expression of serotonin receptor 5-HT7 (5-HT7TR) as well as its downstream effector Cdc42 is upregulated in dendritic cells upon maturation. Although dendritic cell maturation was independent of 5-HT7TR, receptor stimulation affected dendritic cell morphology through Cdc42-mediated signaling. In addition, basal activity of 5-HT7TR was required for the proper expression of the chemokine receptor CCR7, which is a key factor that controls dendritic cell migration. Consistent with this, we observed that 5-HT7TR enhances chemotactic motility of dendritic cells in vitro by modulating their directionality and migration velocity. Accordingly, migration of dendritic cells in murine colon explants was abolished after pharmacological receptor inhibition. Our results indicate that there is a crucial role for 5-HT7TR-Cdc42-mediated signaling in the regulation of dendritic cell morphology and motility, suggesting that 5-HT7TR could be a new target for treatment of a variety of inflammatory and immune disorders.","lang":"eng"}],"language":[{"iso":"eng"}],"issue":"15","oa_version":"None","publication_status":"published","citation":{"ista":"Holst K, Guseva D, Schindler S, Sixt MK, Braun A, Chopra H, Pabst O, Ponimaskin E. 2015. The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. Journal of Cell Science. 128(15), 2866–2880.","mla":"Holst, Katrin, et al. “The Serotonin Receptor 5-HT7R Regulates the Morphology and Migratory Properties of Dendritic Cells.” <i>Journal of Cell Science</i>, vol. 128, no. 15, Company of Biologists, 2015, pp. 2866–80, doi:<a href=\"https://doi.org/10.1242/jcs.167999\">10.1242/jcs.167999</a>.","short":"K. Holst, D. Guseva, S. Schindler, M.K. Sixt, A. Braun, H. Chopra, O. Pabst, E. Ponimaskin, Journal of Cell Science 128 (2015) 2866–2880.","apa":"Holst, K., Guseva, D., Schindler, S., Sixt, M. K., Braun, A., Chopra, H., … Ponimaskin, E. (2015). The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. <i>Journal of Cell Science</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.167999\">https://doi.org/10.1242/jcs.167999</a>","chicago":"Holst, Katrin, Daria Guseva, Susann Schindler, Michael K Sixt, Armin Braun, Himpriya Chopra, Oliver Pabst, and Evgeni Ponimaskin. “The Serotonin Receptor 5-HT7R Regulates the Morphology and Migratory Properties of Dendritic Cells.” <i>Journal of Cell Science</i>. Company of Biologists, 2015. <a href=\"https://doi.org/10.1242/jcs.167999\">https://doi.org/10.1242/jcs.167999</a>.","ama":"Holst K, Guseva D, Schindler S, et al. The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells. <i>Journal of Cell Science</i>. 2015;128(15):2866-2880. doi:<a href=\"https://doi.org/10.1242/jcs.167999\">10.1242/jcs.167999</a>","ieee":"K. Holst <i>et al.</i>, “The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells,” <i>Journal of Cell Science</i>, vol. 128, no. 15. Company of Biologists, pp. 2866–2880, 2015."},"scopus_import":1,"doi":"10.1242/jcs.167999"}