---
res:
bibo_abstract:
- 'Polygenic variation can be maintained by a balance between mutation and stabilizing
selection. When the alleles responsible for variation are rare, many classes of
equilibria may be stable. The rate at which drift causes shifts between equilibria
is investigated by integrating the gene frequency distribution W2N II (pq)4N mu-1.
This integral can be found exactly, by numerical integration, or can be approximated
by assuming that the full distribution of allele frequencies is approximately
Gaussian. These methods are checked against simulations. Over a wide range of
population sizes, drift will keep the population near an equilibrium which minimizes
the genetic variance and the deviation from the selective optimum. Shifts between
equilibria in this class occur at an appreciable rate if the product of population
size and selection on each locus is small (Ns alpha 2 less than 10). The Gaussian
approximation is accurate even when the underlying distribution is strongly skewed.
Reproductive isolation evolves as populations shift to new combinations of alleles:
however, this process is slow, approaching the neutral rate (approximately mu)
in small populations.@eng'
bibo_authorlist:
- foaf_Person:
foaf_givenName: Nicholas H
foaf_name: Nicholas Barton
foaf_surname: Barton
foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
orcid: 0000-0002-8548-5240
bibo_doi: 10.1017/S0016672300028378
bibo_issue: '1'
bibo_volume: 54
dct_date: 1989^xs_gYear
dct_publisher: Cambridge University Press@
dct_title: The divergence of a polygenic system under stabilising selection, mutation
and drift@
...