Partridge, Linda; Barton, Nick HISTA
Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge.
We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey. A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful comments and C. Roper for providing the data for Fig. 1. Our work was supported by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.
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Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. Nature. 1993;362:305-311. doi:10.1038/362305a0
Partridge, L., & Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. Nature. Nature Publishing Group. https://doi.org/10.1038/362305a0
Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” Nature. Nature Publishing Group, 1993. https://doi.org/10.1038/362305a0.
L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” Nature, vol. 362. Nature Publishing Group, pp. 305–311, 1993.
Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.
Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” Nature, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:10.1038/362305a0.
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