Optimality, mutation and the evolution of ageing

L. Partridge, N.H. Barton, Nature 362 (1993) 305–311.

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Abstract
Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge.
Publishing Year
Date Published
1993-03-25
Journal Title
Nature
Volume
362
Page
305 - 311
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Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. Nature. 1993;362:305-311. doi:10.1038/362305a0
Partridge, L., & Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. Nature, 362, 305–311. https://doi.org/10.1038/362305a0
Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” Nature 362 (1993): 305–11. https://doi.org/10.1038/362305a0.
L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” Nature, vol. 362, pp. 305–311, 1993.
Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.
Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” Nature, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:10.1038/362305a0.

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