--- res: bibo_abstract: - Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL) — the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Nicholas H foaf_name: Barton, Nicholas H foaf_surname: Barton foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8548-5240 - foaf_Person: foaf_givenName: Peter foaf_name: Keightley, Peter foaf_surname: Keightley bibo_doi: 10.1038/nrg700 bibo_volume: 3 dct_date: 2002^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/1471-0056 dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Understanding quantitative genetic variation@ fabio_hasPubmedId: '11823787' ...