The effects of genetic and geographic structure on neutral variation

B. Charlesworth, D. Charlesworth, N.H. Barton, Annual Review of Ecology and Systematics 34 (2003) 99–125.

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Abstract
Variation within a species may be structured both geographically and by genetic background. We review the effects of such structuring on neutral variants, using a framework based on the coalescent process. Short-term effects of sex differences and age structure can be averaged out using fast timescale approximations, allowing a simple general treatment of effective population size and migration. We consider the effects of geographic structure on variation within and between local populations, first in general terms, and then for specific migration models. We discuss the close parallels between geographic structure and stable types of genetic structure caused by selection, including balancing selection and background selection. The effects of departures from stability, such as selective sweeps and population bottlenecks, are also described. Methods for distinguishing population history from the effects of ongoing gene flow are discussed. We relate the theoretical results to observed patterns of variation in natural populations.
Publishing Year
Date Published
2003-11-01
Journal Title
Annual Review of Ecology and Systematics
Volume
34
Page
99 - 125
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Charlesworth B, Charlesworth D, Barton NH. The effects of genetic and geographic structure on neutral variation. Annual Review of Ecology and Systematics. 2003;34:99-125. doi:10.1146/annurev.ecolsys.34.011802.132359
Charlesworth, B., Charlesworth, D., & Barton, N. H. (2003). The effects of genetic and geographic structure on neutral variation. Annual Review of Ecology and Systematics, 34, 99–125. https://doi.org/10.1146/annurev.ecolsys.34.011802.132359
Charlesworth, Brian, Deborah Charlesworth, and Nicholas H Barton. “The Effects of Genetic and Geographic Structure on Neutral Variation.” Annual Review of Ecology and Systematics 34 (2003): 99–125. https://doi.org/10.1146/annurev.ecolsys.34.011802.132359.
B. Charlesworth, D. Charlesworth, and N. H. Barton, “The effects of genetic and geographic structure on neutral variation,” Annual Review of Ecology and Systematics, vol. 34, pp. 99–125, 2003.
Charlesworth B, Charlesworth D, Barton NH. 2003. The effects of genetic and geographic structure on neutral variation. Annual Review of Ecology and Systematics. 34, 99–125.
Charlesworth, Brian, et al. “The Effects of Genetic and Geographic Structure on Neutral Variation.” Annual Review of Ecology and Systematics, vol. 34, Annual Reviews, 2003, pp. 99–125, doi:10.1146/annurev.ecolsys.34.011802.132359.

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