Theoretical models of selection and mutationon quantitative traits

T. Johnson, N.H. Barton, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360 (2005) 1411–1425.


Journal Article | Published
Author
;
Abstract
Empirical studies of quantitative genetic variation have revealed robust patterns that are observed both across traits and across species. However, these patterns have no compelling explanation, and some of the observations even appear to be mutually incompatible. We review and extend a major class of theoretical models, ‘mutation–selection models’, that have been proposed to explain quantitative genetic variation. We also briefly review an alternative class of ‘balancing selection models’. We consider to what extent the models are compatible with the general observations, and argue that a key issue is understanding and modelling pleiotropy. We discuss some
Publishing Year
Date Published
2005-07-29
Journal Title
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Volume
360
Issue
1459
Page
1411 - 1425
IST-REx-ID

Cite this

Johnson T, Barton NH. Theoretical models of selection and mutationon quantitative traits. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 2005;360(1459):1411-1425. doi:10.1098/rstb.2005.1667
Johnson, T., & Barton, N. H. (2005). Theoretical models of selection and mutationon quantitative traits. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360(1459), 1411–1425. https://doi.org/10.1098/rstb.2005.1667
Johnson, Toby, and Nicholas H Barton. “Theoretical Models of Selection and Mutationon Quantitative Traits.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360, no. 1459 (2005): 1411–25. https://doi.org/10.1098/rstb.2005.1667.
T. Johnson and N. H. Barton, “Theoretical models of selection and mutationon quantitative traits,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 360, no. 1459, pp. 1411–1425, 2005.
Johnson T, Barton NH. 2005. Theoretical models of selection and mutationon quantitative traits. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360(1459), 1411–1425.
Johnson, Toby, and Nicholas H. Barton. “Theoretical Models of Selection and Mutationon Quantitative Traits.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 360, no. 1459, Royal Society, The, 2005, pp. 1411–25, doi:10.1098/rstb.2005.1667.

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