Kinetics of morphogen gradient formation

A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Julicher, M. Gonzalez Gaitan, Science 315 (2007) 521–525.

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In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg) form gradients of concentration providing positional information. Dpp forms a longer-range gradient than Wg. To understand how the range is controlled, we measured the four key kinetic parameters governing morphogen spreading: the production rate, the effective diffusion coefficient, the degradation rate, and the immobile fraction. The four parameters had different values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different: Dpp spreading requires endocytic, intracellular trafficking.
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521 - 525

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Kicheva A, Pantazis P, Bollenbach T, et al. Kinetics of morphogen gradient formation. Science. 2007;315(5811):521-525. doi:10.1126/science.1135774
Kicheva, A., Pantazis, P., Bollenbach, T., Kalaidzidis, Y., Bittig, T., Julicher, F., & Gonzalez Gaitan, M. (2007). Kinetics of morphogen gradient formation. Science, 315(5811), 521–525.
Kicheva, Anna, Periklis Pantazis, Tobias Bollenbach, Yannis Kalaidzidis, Thomas Bittig, Frank Julicher, and Marcos Gonzalez Gaitan. “Kinetics of Morphogen Gradient Formation.” Science 315, no. 5811 (2007): 521–25.
A. Kicheva et al., “Kinetics of morphogen gradient formation,” Science, vol. 315, no. 5811, pp. 521–525, 2007.
Kicheva A, Pantazis P, Bollenbach T, Kalaidzidis Y, Bittig T, Julicher F, Gonzalez Gaitan M. 2007. Kinetics of morphogen gradient formation. Science. 315(5811), 521–525.
Kicheva, Anna, et al. “Kinetics of Morphogen Gradient Formation.” Science, vol. 315, no. 5811, American Association for the Advancement of Science, 2007, pp. 521–25, doi:10.1126/science.1135774.


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