{"date_created":"2018-12-11T12:07:36Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","issue":"1","language":[{"iso":"eng"}],"date_published":"1996-12-01T00:00:00Z","external_id":{"pmid":["9007232"]},"publication_status":"published","intvolume":"       123","publisher":"Company of Biologists","title":"Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo","extern":"1","abstract":[{"lang":"eng","text":"We describe two genes, dino and mercedes, which are required for the organization of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the expense of the head and the anterior region of the trunk, The altered expression patterns of various marker genes reveal that, with the exception of the dorsal most marginal zone, all regions of the early dine mutant embryo acquire more ventral fates, These alterations are already apparent before the onset of gastrulation, mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes. The phenotypes suggests that dine and mercedes are required for the establishment of dorsal fates in both the marginal and the animal zone of the early gastrula embryo, Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo."}],"quality_controlled":"1","date_updated":"2022-08-04T15:10:34Z","pmid":1,"publication_identifier":{"issn":["0950-1991"]},"article_type":"original","month":"12","year":"1996","acknowledgement":"We are very grateful to Dr Andrew McMahon in whose laboratory much of the mutant analysis has been carried out. Additionally, we would like to thank Ed Sullivan for his help and advice during the setting up of a fish facility in the McMahon laboratory. Drs Eric Weinberg and Leonard Zon generously supplied us with reagents prior to publication. Published reagents were obtained from Drs Jon Graff, Jean-Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.\r\nDrs Mary Dickinson, Andrew McMahon, Siegfried Roth and Stefan Schulte-Merker read earlier versions of the Manuscript. ","oa_version":"None","article_processing_charge":"No","day":"01","author":[{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"first_name":"Francisco","full_name":"Pelegri, Francisco","last_name":"Pelegri"},{"first_name":"Mary","full_name":"Mullins, Mary","last_name":"Mullins"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"first_name":"Fredericus","full_name":"Van Eeden, Fredericus","last_name":"Van Eeden"},{"last_name":"Granato","first_name":"Michael","full_name":"Granato, Michael"},{"last_name":"Brand","first_name":"Michael","full_name":"Brand, Michael"},{"last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto","first_name":"Makoto"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"first_name":"Robert","full_name":"Kelsh, Robert","last_name":"Kelsh"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"last_name":"Warga","first_name":"Rachel","full_name":"Warga, Rachel"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"doi":"10.1242/dev.123.1.95","_id":"4211","publist_id":"1907","type":"journal_article","status":"public","publication":"Development","scopus_import":"1","volume":123,"citation":{"ieee":"M. Hammerschmidt <i>et al.</i>, “Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 95–102, 1996.","mla":"Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 95–102, doi:<a href=\"https://doi.org/10.1242/dev.123.1.95\">10.1242/dev.123.1.95</a>.","ama":"Hammerschmidt M, Pelegri F, Mullins M, et al. Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. <i>Development</i>. 1996;123(1):95-102. doi:<a href=\"https://doi.org/10.1242/dev.123.1.95\">10.1242/dev.123.1.95</a>","ista":"Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand M, Furutani Seiki M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 123(1), 95–102.","apa":"Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato, M., … Nüsslein Volhard, C. (1996). Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.95\">https://doi.org/10.1242/dev.123.1.95</a>","chicago":"Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane, Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.95\">https://doi.org/10.1242/dev.123.1.95</a>.","short":"M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato, M. Brand, M. Furutani Seiki, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102."},"page":"95 - 102"}