dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato, M. Brand, M. Furutani Seiki, P. Haffter, C. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102.

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Abstract
We describe two genes, dino and mercedes, which are required for the organization of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the expense of the head and the anterior region of the trunk, The altered expression patterns of various marker genes reveal that, with the exception of the dorsal most marginal zone, all regions of the early dine mutant embryo acquire more ventral fates, These alterations are already apparent before the onset of gastrulation, mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes. The phenotypes suggests that dine and mercedes are required for the establishment of dorsal fates in both the marginal and the animal zone of the early gastrula embryo, Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo.
Publishing Year
Date Published
1996-12-01
Journal Title
Development
Volume
123
Page
95 - 102
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Hammerschmidt M, Pelegri F, Mullins M, et al. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 1996;123:95-102.
Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato, M., … Nüsslein Volhard, C. (1996). dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development, 123, 95–102.
Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane, Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” Development 123 (1996): 95–102.
M. Hammerschmidt et al., “dino and mercedes, two genes regulating dorsal development in the zebrafish embryo,” Development, vol. 123, pp. 95–102, 1996.
Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand M, Furutani Seiki M, Haffter P, Heisenberg C, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 123, 95–102.
Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” Development, vol. 123, Company of Biologists, 1996, pp. 95–102.

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