Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients

K. Dasbiswas, C.-E.B. Hannezo, N. Gov, Biophysical Journal 114 (2018) 968–977.


Journal Article | Published | English
Author
; ;
Department
Abstract
Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration-dependent manner—and whose spatial profile in turn is affected by cell shape. We map out theoretically the possible interplay between chemical concentration and cellular structure. Besides providing a direct route to spatial gradients in cell shape profiles in tissues, we show that the dependence on cell shape helps create robust mechanochemical gradients.
Publishing Year
Date Published
2018-02-27
Journal Title
Biophysical Journal
Volume
114
Issue
4
Page
968 - 977
IST-REx-ID

Cite this

Dasbiswas K, Hannezo C-EB, Gov N. Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients. Biophysical Journal. 2018;114(4):968-977. doi:10.1016/j.bpj.2017.12.022
Dasbiswas, K., Hannezo, C.-E. B., & Gov, N. (2018). Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients. Biophysical Journal, 114(4), 968–977. https://doi.org/10.1016/j.bpj.2017.12.022
Dasbiswas, Kinjal, Claude-Edouard B Hannezo, and Nir Gov. “Theory of Eppithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.” Biophysical Journal 114, no. 4 (2018): 968–77. https://doi.org/10.1016/j.bpj.2017.12.022.
K. Dasbiswas, C.-E. B. Hannezo, and N. Gov, “Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients,” Biophysical Journal, vol. 114, no. 4, pp. 968–977, 2018.
Dasbiswas K, Hannezo C-EB, Gov N. 2018. Theory of eppithelial cell shape transitions induced by mechanoactive chemical gradients. Biophysical Journal. 114(4), 968–977.
Dasbiswas, Kinjal, et al. “Theory of Eppithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.” Biophysical Journal, vol. 114, no. 4, Biophysical Society, 2018, pp. 968–77, doi:10.1016/j.bpj.2017.12.022.

Link(s) to Main File(s)
Access Level
OA Open Access

Export

Marked Publications

Open Data IST Research Explorer

Sources

arXiv 1709.01486

Search this title in

Google Scholar