Planar cell polarization requires Widerborst, a B ' regulatory subunit of protein phosphatase 2A

M. Hannus, F. Feiguin, C. Heisenberg, S. Eaton, Development 129 (2002) 3493–3503.

Download
No fulltext has been uploaded. References only!
Journal Article | Published
Author
; ; ;
Abstract
We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms.
Publishing Year
Date Published
2002-07-15
Journal Title
Development
Volume
129
Issue
14
Page
3493 - 3503
IST-REx-ID

Cite this

Hannus M, Feiguin F, Heisenberg C, Eaton S. Planar cell polarization requires Widerborst, a B ’ regulatory subunit of protein phosphatase 2A. Development. 2002;129(14):3493-3503.
Hannus, M., Feiguin, F., Heisenberg, C., & Eaton, S. (2002). Planar cell polarization requires Widerborst, a B ’ regulatory subunit of protein phosphatase 2A. Development, 129(14), 3493–3503.
Hannus, Michael, Fabian Feiguin, Carl Heisenberg, and Suzanne Eaton. “Planar Cell Polarization Requires Widerborst, a B ’ Regulatory Subunit of Protein Phosphatase 2A.” Development 129, no. 14 (2002): 3493–3503.
M. Hannus, F. Feiguin, C. Heisenberg, and S. Eaton, “Planar cell polarization requires Widerborst, a B ’ regulatory subunit of protein phosphatase 2A,” Development, vol. 129, no. 14, pp. 3493–3503, 2002.
Hannus M, Feiguin F, Heisenberg C, Eaton S. 2002. Planar cell polarization requires Widerborst, a B ’ regulatory subunit of protein phosphatase 2A. Development. 129(14), 3493–3503.
Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B ’ Regulatory Subunit of Protein Phosphatase 2A.” Development, vol. 129, no. 14, Company of Biologists, 2002, pp. 3493–503.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar