The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion

Von Der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica Krezel L, Heisenberg C-PJ, Hammerschmidt M. 2007. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Current Biology. 17(6), 475–487.

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Journal Article | Published | English
Author
Von Der Hardt, Sophia; Bakkers, Jeroen; Inbal, Adi; Carvalho, Lara; Solnica Krezel, Lilianna; Heisenberg, Carl-Philipp IST Austria ; Hammerschmidt, Matthias
Abstract
Background: Bone morphogenetic proteins (Bmps) are required for the specification of ventrolateral cell fates during embryonic dorsoventral patterning and for proper convergence and extension gastrulation movements, but the mechanisms underlying the latter role remained elusive. Results: Via bead implantations, we show that the Bmp gradient determines the direction of lateral mesodermal cell migration during dorsal convergence in the zebrafish gastrula. This effect is independent of its role during dorsoventral patterning and of noncanonical Wnt signaling. However, it requires Bmp signal transduction through AIk8 and Smad5 to negatively regulate Ca2+/Cadherin-dependent cell-cell adhesiveness. In vivo, converging mesodermal cells form lamellipodia that attach to adjacent cells. Bmp signaling diminishes the Cadherin-dependent stability of such contact points, thereby abrogating subsequent cell displacement during lamellipodial retraction. Conclusions: We propose that the ventral-to-dorsal Bmp gradient has an instructive role to establish a reverse gradient of cell-cell adhesiveness, thereby defining different migratory zones and directing lamellipodia-driven cell migrations during dorsal convergence in lateral regions of the zebrafish gastrula.
Publishing Year
Date Published
2007-03-20
Journal Title
Current Biology
Volume
17
Issue
6
Page
475 - 487
IST-REx-ID

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Von Der Hardt S, Bakkers J, Inbal A, et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Current Biology. 2007;17(6):475-487. doi:10.1016/j.cub.2007.02.013
Von Der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica Krezel, L., Heisenberg, C.-P. J., & Hammerschmidt, M. (2007). The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2007.02.013
Von Der Hardt, Sophia, Jeroen Bakkers, Adi Inbal, Lara Carvalho, Lilianna Solnica Krezel, Carl-Philipp J Heisenberg, and Matthias Hammerschmidt. “The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion.” Current Biology. Cell Press, 2007. https://doi.org/10.1016/j.cub.2007.02.013.
S. Von Der Hardt et al., “The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion,” Current Biology, vol. 17, no. 6. Cell Press, pp. 475–487, 2007.
Von Der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica Krezel L, Heisenberg C-PJ, Hammerschmidt M. 2007. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Current Biology. 17(6), 475–487.
Von Der Hardt, Sophia, et al. “The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion.” Current Biology, vol. 17, no. 6, Cell Press, 2007, pp. 475–87, doi:10.1016/j.cub.2007.02.013.

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