--- res: bibo_abstract: - Seeds derive from ovules upon fertilization and therefore the total number of ovules determines the final seed yield, a fundamental trait in crop plants. Among the factors that co-ordinate the process of ovule formation, the transcription factors CUP-SHAPED COTYLEDON 1 (CUC1) and CUC2 and the hormone cytokinin (CK) have a particularly prominent role. Indeed, the absence of both CUC1 and CUC2 causes a severe reduction in ovule number, a phenotype that can be rescued by CK treatment. In this study, we combined CK quantification with an integrative genome-wide target identification approach to select Arabidopsis genes regulated by CUCs that are also involved in CK metabolism. We focused our attention on the functional characterization of UDP-GLUCOSYL TRANSFERASE 85A3 (UGT85A3) and UGT73C1, which are up-regulated in the absence of CUC1 and CUC2 and encode enzymes able to catalyse CK inactivation by O-glucosylation. Our results demonstrate a role for these UGTs as a link between CUCs and CK homeostasis, and highlight the importance of CUCs and CKs in the determination of seed yield.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Mara foaf_name: Cucinotta, Mara foaf_surname: Cucinotta - foaf_Person: foaf_givenName: Silvia foaf_name: Manrique, Silvia foaf_surname: Manrique - foaf_Person: foaf_givenName: Candela foaf_name: Cuesta, Candela foaf_surname: Cuesta foaf_workInfoHomepage: http://www.librecat.org/personId=33A3C818-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-1923-2410 - foaf_Person: foaf_givenName: Eva foaf_name: Benková, Eva foaf_surname: Benková foaf_workInfoHomepage: http://www.librecat.org/personId=38F4F166-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8510-9739 - foaf_Person: foaf_givenName: Ondřej foaf_name: Novák, Ondřej foaf_surname: Novák - foaf_Person: foaf_givenName: Lucia foaf_name: Colombo, Lucia foaf_surname: Colombo bibo_doi: 10.1093/jxb/ery281 bibo_issue: '21' bibo_volume: 69 dct_date: 2018^xs_gYear dct_identifier: - UT:000448163900015 dct_language: eng dct_publisher: Oxford University Press@ dct_title: Cup-shaped Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis to determine ovule number in arabidopsis@ ...