--- res: bibo_abstract: - Vertebrate gastrulation involves the specification and coordinated movement of large populations of cells that give rise to the ectodermal, mesodermal and endodermal germ layers. Although many of the genes involved in the specification of cell identity during this process have been identified, little is known of the genes that coordinate cell movement. Here we show that the zebrafish silberblick (slb) locus(1) encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation. In the absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia and other midline defects in the head(2). The requirement for Slb/Wnt11 is cell non-autonomous, and our results indicate that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue. We also show that the slb phenotype is rescued by a truncated form of Dishevelled that does not signal through the canonical Wnt pathway(3), suggesting that, as in flies(4), Wnt signalling might mediate morphogenetic events through a divergent signal transduction cascade. Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Carl-Philipp J foaf_name: Heisenberg, Carl-Philipp J foaf_surname: Heisenberg foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-0912-4566 - foaf_Person: foaf_givenName: Masazumi foaf_name: Tada, Masazumi foaf_surname: Tada - foaf_Person: foaf_givenName: Gerd foaf_name: Rauch, Gerd foaf_surname: Rauch - foaf_Person: foaf_givenName: Leonor foaf_name: Saúde, Leonor foaf_surname: Saúde - foaf_Person: foaf_givenName: Miguel foaf_name: Concha, Miguel foaf_surname: Concha - foaf_Person: foaf_givenName: Robert foaf_name: Geisler, Robert foaf_surname: Geisler - foaf_Person: foaf_givenName: Derek foaf_name: Stemple, Derek foaf_surname: Stemple - foaf_Person: foaf_givenName: James foaf_name: Smith, James foaf_surname: Smith - foaf_Person: foaf_givenName: Stephen foaf_name: Wilson, Stephen foaf_surname: Wilson bibo_doi: 10.1038/35011068 bibo_issue: '6782' bibo_volume: 405 dct_date: 2000^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0028-0836 dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation@ fabio_hasPubmedId: '10811221 ' ...