Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons

C. Heisenberg, H. Thoenen, D. Lindholm, Neuroreport 3 (1992) 685–688.

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Abstract
The effects of tri-iodothyronine (T3), which are known to affect cerebellar development, were tested on neuronal survival and differentiation of cultured cerebellar granule neurons. T3 in physiological concentrations increased both granule neuron survival after three days in culture and synaptic vesicle protein formation, as shown by immunostaining with antibodies against synaptophysin. Likewise, T3 increased the mRNA level for synapsin(I), but not that for GAP43 in granule neurons. Antibodies against microtubule associated protein Tau, which is expressed in developing neurites, showed that T3 also enhanced neurite formation.
Publishing Year
Date Published
1992-01-01
Journal Title
Neuroreport
Volume
3
Issue
8
Page
685 - 688
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Heisenberg C, Thoenen H, Lindholm D. Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 1992;3(8):685-688.
Heisenberg, C., Thoenen, H., & Lindholm, D. (1992). Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport, 3(8), 685–688.
Heisenberg, Carl, Hans Thoenen, and Dan Lindholm. “Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport 3, no. 8 (1992): 685–88.
C. Heisenberg, H. Thoenen, and D. Lindholm, “Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons,” Neuroreport, vol. 3, no. 8, pp. 685–688, 1992.
Heisenberg C, Thoenen H, Lindholm D. 1992. Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 3(8), 685–688.
Heisenberg, Carl, et al. “Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport, vol. 3, no. 8, Lippincott, Williams & Wilkins, 1992, pp. 685–88.

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