{"publication":"Development","volume":123,"oa_version":"None","status":"public","_id":"4191","acknowledgement":"We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield, Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J. J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).","abstract":[{"text":"In a screen for embryonic mutants in the zebrafish a large number of mutants were isolated with abnormal brain morphology, We describe here 26 mutants in 13 complementation groups that show abnormal development of large regions of the brain, Early neurogenesis is affected in white tail (wit), During segmentation stages, homozygous wit embryos display an irregularly formed neural keel, particularly in the hindbrain, Using a variety of molecular markers, a severe increase in the number of various early differentiating neurons can be demonstrated, In contrast, late differentiating neurons, radial glial cells and some nonneural cell types, such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis appears delayed, In addition, very reduced numbers of melanophores are present posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general organization of the hindbrain is disturbed and many rounded cells accumulate loosely in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk), natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop collapsed brain ventricles, before showing signs of general degeneration, atlantis (atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele) mutants have different malformation of the brain folds, Some of them have transient phenotypes, and mutant individuals may grow up to adults.","lang":"eng"}],"doi":"10.1242/dev.123.1.205","publication_identifier":{"issn":["0950-1991"]},"month":"12","author":[{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"first_name":"Michael","last_name":"Brand","full_name":"Brand, Michael"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"},{"full_name":"Beuchle, Dirk","last_name":"Beuchle","first_name":"Dirk"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"first_name":"Robert","last_name":"Kelsh","full_name":"Kelsh, Robert"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"first_name":"Michael","last_name":"Granato","full_name":"Granato, Michael"},{"last_name":"Haffter","full_name":"Haffter, Pascal","first_name":"Pascal"},{"first_name":"Matthias","last_name":"Hammerschmidt","full_name":"Hammerschmidt, Matthias"},{"last_name":"Kane","full_name":"Kane, Donald","first_name":"Donald"},{"first_name":"Mary","last_name":"Mullins","full_name":"Mullins, Mary"},{"full_name":"Odenthal, Jörg","last_name":"Odenthal","first_name":"Jörg"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard"}],"date_created":"2018-12-11T12:07:30Z","scopus_import":"1","intvolume":"       123","title":"Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio","day":"01","citation":{"apa":"Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M., Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.205\">https://doi.org/10.1242/dev.123.1.205</a>","ieee":"Y. Jiang <i>et al.</i>, “Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 205–216, 1996.","mla":"Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 205–16, doi:<a href=\"https://doi.org/10.1242/dev.123.1.205\">10.1242/dev.123.1.205</a>.","chicago":"Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle, Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.205\">https://doi.org/10.1242/dev.123.1.205</a>.","ista":"Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development. 123(1), 205–216.","short":"Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R. Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins, J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.","ama":"Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):205-216. doi:<a href=\"https://doi.org/10.1242/dev.123.1.205\">10.1242/dev.123.1.205</a>"},"issue":"1","year":"1996","date_updated":"2022-08-05T09:13:51Z","publication_status":"published","extern":"1","publisher":"Company of Biologists","page":"205 - 216","type":"journal_article","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_type":"original","quality_controlled":"1","language":[{"iso":"eng"}],"pmid":1,"publist_id":"1926","external_id":{"pmid":["9007241"]},"date_published":"1996-12-01T00:00:00Z"}