--- _id: '4186' abstract: - lang: eng text: 'Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation, Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development, As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation, By complementation analysis, we define 94 genes, We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected, Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation, Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation, Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation, 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival, In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.' acknowledgement: We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral Fellowship. article_processing_charge: No article_type: original author: - first_name: Robert full_name: Kelsh, Robert last_name: Kelsh - first_name: Michael full_name: Brand, Michael last_name: Brand - first_name: Yunjin full_name: Jiang, Yunjin last_name: Jiang - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Shuo full_name: Lin, Shuo last_name: Lin - first_name: Pascal full_name: Haffter, Pascal last_name: Haffter - first_name: Jörg full_name: Odenthal, Jörg last_name: Odenthal - first_name: Mary full_name: Mullins, Mary last_name: Mullins - first_name: Fredericus full_name: Van Eeden, Fredericus last_name: Van Eeden - first_name: Makoto full_name: Furutani Seiki, Makoto last_name: Furutani Seiki - first_name: Michael full_name: Granato, Michael last_name: Granato - first_name: Matthias full_name: Hammerschmidt, Matthias last_name: Hammerschmidt - first_name: Donald full_name: Kane, Donald last_name: Kane - first_name: Rachel full_name: Warga, Rachel last_name: Warga - first_name: Dirk full_name: Beuchle, Dirk last_name: Beuchle - first_name: Lisa full_name: Vogelsang, Lisa last_name: Vogelsang - first_name: Christiane full_name: Nüsslein Volhard, Christiane last_name: Nüsslein Volhard citation: ama: Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123(1):369-389. doi:10.1242/dev.123.1.369 apa: Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P., … Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes of neural crest development. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.369 chicago: Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg, Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations and the Processes of Neural Crest Development.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.369. ieee: R. Kelsh et al., “Zebrafish pigmentation mutations and the processes of neural crest development,” Development, vol. 123, no. 1. Company of Biologists, pp. 369–389, 1996. ista: Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J, Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D, Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 123(1), 369–389. mla: Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of Neural Crest Development.” Development, vol. 123, no. 1, Company of Biologists, 1996, pp. 369–89, doi:10.1242/dev.123.1.369. short: R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J. Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development 123 (1996) 369–389. date_created: 2018-12-11T12:07:28Z date_published: 1996-12-01T00:00:00Z date_updated: 2022-08-05T11:16:49Z day: '01' doi: 10.1242/dev.123.1.369 extern: '1' external_id: pmid: - '9007256 ' intvolume: ' 123' issue: '1' language: - iso: eng month: '12' oa_version: None page: 369 - 389 pmid: 1 publication: Development publication_identifier: issn: - 0950-1991 publication_status: published publisher: Company of Biologists publist_id: '1933' quality_controlled: '1' scopus_import: '1' status: public title: Zebrafish pigmentation mutations and the processes of neural crest development type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 123 year: '1996' ...