The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation

B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, C. Heisenberg, Mechanisms of Development 120 (2003) 467–476.

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Abstract
Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Publishing Year
Date Published
2003-04-01
Journal Title
Mechanisms of Development
Volume
120
Issue
4
Page
467 - 476
IST-REx-ID

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Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development. 2003;120(4):467-476. doi:10.1016/S0925-4773(03)00004-2
Kilian, B., Mansukoski, H., Barbosa, F., Ulrich, F., Tada, M., & Heisenberg, C. (2003). The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development, 120(4), 467–476. https://doi.org/10.1016/S0925-4773(03)00004-2
Kilian, Beate, Hannu Mansukoski, Filipa Barbosa, Florian Ulrich, Masazumi Tada, and Carl Heisenberg. “The Role of Ppt/Wnt5 in Regulating Cell Shape and Movement during Zebrafish Gastrulation.” Mechanisms of Development 120, no. 4 (2003): 467–76. https://doi.org/10.1016/S0925-4773(03)00004-2.
B. Kilian, H. Mansukoski, F. Barbosa, F. Ulrich, M. Tada, and C. Heisenberg, “The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation,” Mechanisms of Development, vol. 120, no. 4, pp. 467–476, 2003.
Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C. 2003. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mechanisms of Development. 120(4), 467–476.
Kilian, Beate, et al. “The Role of Ppt/Wnt5 in Regulating Cell Shape and Movement during Zebrafish Gastrulation.” Mechanisms of Development, vol. 120, no. 4, Elsevier, 2003, pp. 467–76, doi:10.1016/S0925-4773(03)00004-2.

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