--- _id: '4157' abstract: - lang: eng text: Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis. acknowledged_ssus: - _id: Bio author: - first_name: Ekaterina full_name: Papusheva, Ekaterina id: 41DB591E-F248-11E8-B48F-1D18A9856A87 last_name: Papusheva - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 citation: ama: 'Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 2010;29(16):2753-2768. doi:10.1038/emboj.2010.182' apa: 'Papusheva, E., & Heisenberg, C.-P. J. (2010). Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1038/emboj.2010.182' chicago: 'Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” EMBO Journal. Wiley-Blackwell, 2010. https://doi.org/10.1038/emboj.2010.182.' ieee: 'E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis,” EMBO Journal, vol. 29, no. 16. Wiley-Blackwell, pp. 2753–2768, 2010.' ista: 'Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.' mla: 'Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” EMBO Journal, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:10.1038/emboj.2010.182.' short: E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768. date_created: 2018-12-11T12:07:17Z date_published: 2010-08-18T00:00:00Z date_updated: 2021-01-12T07:54:55Z day: '18' department: - _id: Bio - _id: CaHe doi: 10.1038/emboj.2010.182 external_id: pmid: - '20717145' intvolume: ' 29' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924654/ month: '08' oa: 1 oa_version: Submitted Version page: 2753 - 2768 pmid: 1 publication: EMBO Journal publication_status: published publisher: Wiley-Blackwell publist_id: '1962' quality_controlled: '1' scopus_import: 1 status: public title: 'Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis' type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 29 year: '2010' ...