Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis

E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768.


Journal Article | Published | English
Abstract
Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.
Publishing Year
Date Published
2010-08-18
Journal Title
EMBO Journal
Acknowledged SSUs
Volume
29
Issue
16
Page
2753 - 2768
IST-REx-ID

Cite this

Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 2010;29(16):2753-2768. doi:10.1038/emboj.2010.182
Papusheva, E., & Heisenberg, C.-P. J. (2010). Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal, 29(16), 2753–2768. https://doi.org/10.1038/emboj.2010.182
Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” EMBO Journal 29, no. 16 (2010): 2753–68. https://doi.org/10.1038/emboj.2010.182.
E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis,” EMBO Journal, vol. 29, no. 16, pp. 2753–2768, 2010.
Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.
Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.” EMBO Journal, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:10.1038/emboj.2010.182.

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PMID: 20717145
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