---
_id: '4156'
abstract:
- lang: eng
text: 'In a large scale screen for mutants that affect the early development of
the zebrafish, 109 mutants were found that cause defects in the formation of the
jaw and the more posterior pharyngeal arches, Here we present the phenotypic description
and results of the complementation analysis of mutants belonging to two major
classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants
with defects in cartilage differentiation and growth in all arches, Mutations
in four of the genes identified during the screen show specific defects in the
first two arches and leave the more posterior pharyngeal arches largely unaffected
(schmerle, sucker, hoover and sturgeon). In these mutants ventral components of
the mandibular and hyoid arches are reduced (Meckel''s cartilage and ceratohyal
cartilage) whereas dorsal structures (palato-quadrate and hyosymplectic cartilages)
are of normal size or enlarged, Thus, mutations in single genes cause defects
in the formation of first and second arch structures but also differentially affect
development of the dorsal and ventral structures within one arch. In 27 mutants
that define at least 8 genes, the differentiation of cartilage and growth is affected.
In hammerhead mutants particularly the mesodermally derived cartilages are reduced,
whereas jellyfish mutant larvae are characterized by a severe reduction of all
cartilaginous elements, leaving only two pieces in the position of the ceratohyal
cartilages. In all other mutant larvae all skeletal elements are present, but
consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened
heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths
of chondrocytes occur along the edges of all cartilaginous elements. The mutants
presented here may be valuable tools for elucidating the genetic mechanisms that
underlie the development of the mandibular and the hyoid arches, as well as the
process of cartilage differentiation.'
acknowledgement: We would like to thank Siegfried Roth, Stefan Schulte-Merker and
Tanya Whitfield for critically reading the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Piotrowski T, Schilling T, Brand M, et al. Jaw and branchial arch mutants
in zebrafish II: Anterior arches and cartilage differentiation. Development.
1996;123(1):345-356. doi:10.1242/dev.123.1.345'
apa: 'Piotrowski, T., Schilling, T., Brand, M., Jiang, Y., Heisenberg, C.-P. J.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in
zebrafish II: Anterior arches and cartilage differentiation. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.345'
chicago: 'Piotrowski, Tatjana, Thomas Schilling, Michael Brand, Yunjin Jiang, Carl-Philipp
J Heisenberg, Dirk Beuchle, Heiner Grandel, et al. “Jaw and Branchial Arch Mutants
in Zebrafish II: Anterior Arches and Cartilage Differentiation.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.345.'
ieee: 'T. Piotrowski et al., “Jaw and branchial arch mutants in zebrafish
II: Anterior arches and cartilage differentiation,” Development, vol. 123,
no. 1. Company of Biologists, pp. 345–356, 1996.'
ista: 'Piotrowski T, Schilling T, Brand M, Jiang Y, Heisenberg C-PJ, Beuchle D,
Grandel H, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996.
Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation. Development. 123(1), 345–356.'
mla: 'Piotrowski, Tatjana, et al. “Jaw and Branchial Arch Mutants in Zebrafish II:
Anterior Arches and Cartilage Differentiation.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 345–56, doi:10.1242/dev.123.1.345.'
short: T. Piotrowski, T. Schilling, M. Brand, Y. Jiang, C.-P.J. Heisenberg, D. Beuchle,
H. Grandel, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt,
D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development
123 (1996) 345–356.
date_created: 2018-12-11T12:07:17Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:13:07Z
day: '01'
doi: 10.1242/dev.123.1.345
extern: '1'
external_id:
pmid:
- '9007254 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 345 - 356
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1963'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...