Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin

F. Ulrich, M. Krieg, E. Schötz, V. Link, I. Castanon, V. Schnabel, A. Taubenberger, D. Müller, P. Puech, C.-P.J. Heisenberg, Developmental Cell 9 (2005) 555–564.

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Journal Article | Published | English
Author
Ulrich, Florian; Krieg, Michael; Schötz, Eva; Link, Vinzenz; Castanon, Irinka; Schnabel, Viktor; Taubenberger, Anna; Müller, Daniel; Puech, Pierre; Heisenberg, Carl-Philipp IST Austria
Abstract
Wnt11 plays a central role in tissue morphogenesis during vertebrate gastrulation, but the molecular and cellular mechanisms by which Wnt11 exerts its effects remain poorly understood. Here, we show that Wnt11 functions during zebrafish gastrulation by regulating the cohesion of mesodermal and endodermal (mesendodermal) progenitor cells. Importantly, we demonstrate that Wnt11 activity in this process is mediated by the GTPase Rab5, a key regulator of early endocytosis, as blocking Rab5c activity in wild-type embryos phenocopies slb/wnt11 mutants, and enhancing Rab5c activity in slb/wnt11 mutant embryos rescues the mutant phenotype. In addition, we find that Wnt11 and Rab5c control the endocytosis of E-cadherin and are required in mesendodermal cells for E-cadherin-mediated cell cohesion. Together, our results suggest that Wnt11 controls tissue morphogenesis by modulating E-cadherin-mediated cell cohesion through Rab5c, a novel mechanism of Wnt signaling in gastrulation.
Publishing Year
Date Published
2005-10-01
Journal Title
Developmental Cell
Volume
9
Issue
4
Page
555 - 564
IST-REx-ID

Cite this

Ulrich F, Krieg M, Schötz E, et al. Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Developmental Cell. 2005;9(4):555-564. doi:10.1016/j.devcel.2005.08.011
Ulrich, F., Krieg, M., Schötz, E., Link, V., Castanon, I., Schnabel, V., … Heisenberg, C.-P. J. (2005). Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Developmental Cell, 9(4), 555–564. https://doi.org/10.1016/j.devcel.2005.08.011
Ulrich, Florian, Michael Krieg, Eva Schötz, Vinzenz Link, Irinka Castanon, Viktor Schnabel, Anna Taubenberger, Daniel Müller, Pierre Puech, and Carl-Philipp J Heisenberg. “Wnt11 Functions in Gastrulation by Controlling Cell Cohesion through Rab5c and E-Cadherin.” Developmental Cell 9, no. 4 (2005): 555–64. https://doi.org/10.1016/j.devcel.2005.08.011.
F. Ulrich et al., “Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin,” Developmental Cell, vol. 9, no. 4, pp. 555–564, 2005.
Ulrich F, Krieg M, Schötz E, Link V, Castanon I, Schnabel V, Taubenberger A, Müller D, Puech P, Heisenberg C-PJ. 2005. Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Developmental Cell. 9(4), 555–564.
Ulrich, Florian, et al. “Wnt11 Functions in Gastrulation by Controlling Cell Cohesion through Rab5c and E-Cadherin.” Developmental Cell, vol. 9, no. 4, Cell Press, 2005, pp. 555–64, doi:10.1016/j.devcel.2005.08.011.

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