---
_id: '4143'
abstract:
- lang: eng
text: 'The migration of single cells and epithelial sheets is of great importance
for gastrulation and organ formation in developing embryos and, if misregulated,
can have dire consequences e.g. during cancer metastasis. A keystone of cell migration
is the regulation of adhesive contacts, which are dynamically assembled and disassembled
via endocytosis. Here, we discuss some of the basic concepts about the function
of endocytic trafficking during cell migration: transport of integrins from the
cell rear to the leading edge in fibroblasts; confinement of signalling to the
front of single cells by endocytic transport of growth factors; regulation of
movement coherence in multicellular sheets by cadherin turnover; and shaping of
extracellular chemokine gradients. Taken together, endocytosis enables migrating
cells and tissues to dynamically modulate their adhesion and signalling, allowing
them to efficiently migrate through their extracellular environment.'
article_processing_charge: No
author:
- first_name: Florian
full_name: Ulrich, Florian
last_name: Ulrich
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Ulrich F, Heisenberg C-PJ. Trafficking and cell migration. Traffic.
2009;10(7):811-818. doi:10.1111/j.1600-0854.2009.00929.x
apa: Ulrich, F., & Heisenberg, C.-P. J. (2009). Trafficking and cell migration.
Traffic. Wiley-Blackwell. https://doi.org/10.1111/j.1600-0854.2009.00929.x
chicago: Ulrich, Florian, and Carl-Philipp J Heisenberg. “Trafficking and Cell Migration.”
Traffic. Wiley-Blackwell, 2009. https://doi.org/10.1111/j.1600-0854.2009.00929.x.
ieee: F. Ulrich and C.-P. J. Heisenberg, “Trafficking and cell migration,” Traffic,
vol. 10, no. 7. Wiley-Blackwell, pp. 811–818, 2009.
ista: Ulrich F, Heisenberg C-PJ. 2009. Trafficking and cell migration. Traffic.
10(7), 811–818.
mla: Ulrich, Florian, and Carl-Philipp J. Heisenberg. “Trafficking and Cell Migration.”
Traffic, vol. 10, no. 7, Wiley-Blackwell, 2009, pp. 811–18, doi:10.1111/j.1600-0854.2009.00929.x.
short: F. Ulrich, C.-P.J. Heisenberg, Traffic 10 (2009) 811–818.
date_created: 2018-12-11T12:07:12Z
date_published: 2009-05-20T00:00:00Z
date_updated: 2021-01-12T07:54:49Z
day: '20'
doi: 10.1111/j.1600-0854.2009.00929.x
extern: '1'
intvolume: ' 10'
issue: '7'
language:
- iso: eng
month: '05'
oa_version: None
page: 811 - 818
publication: Traffic
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1976'
status: public
title: Trafficking and cell migration
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2009'
...