---
_id: '4140'
abstract:
- lang: eng
text: Wnt11 is a key signal, determining cell polarization and migration during
vertebrate gastrulation. It is known that Wnt11 functionally interacts with several
signaling components, the homologues of which control planar cell polarity in
Drosophila melanogaster. Although in D. melanogaster these components are thought
to polarize cells by asymmetrically localizing at the plasma membrane, it is not
yet clear whether their subcellular localization plays a similarly important role
in vertebrates. We show that in zebrafish embryonic cells, Wnt11 locally functions
at the plasma membrane by accumulating its receptor, Frizzled 7, on adjacent sites
of cell contacts. Wnt11-induced Frizzled 7 accumulations recruit the intracellular
Wnt signaling mediator Dishevelled, as well as Wnt11 itself, and locally increase
cell contact persistence. This increase in cell contact persistence is mediated
by the local interaction of Wnt11, Frizzled 7, and the atypical cadherin Flamingo
at the plasma membrane, and it does not require the activity of further downstream
effectors of Wnt11 signaling, such as RhoA and Rok2. We propose that Wnt11, by
interacting with Frizzled 7 and Flamingo, modulates local cell contact persistence
to coordinate cell movements during gastrulation.
article_processing_charge: No
author:
- first_name: Sabine
full_name: Witzel, Sabine
last_name: Witzel
- first_name: Vitaly
full_name: Zimyanin, Vitaly
last_name: Zimyanin
- first_name: Filipa
full_name: Carreira Barbosa, Filipa
last_name: Carreira Barbosa
- first_name: Masazumi
full_name: Tada, Masazumi
last_name: Tada
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Witzel S, Zimyanin V, Carreira Barbosa F, Tada M, Heisenberg C-PJ. Wnt11 controls
cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane.
Journal of Cell Biology. 2006;175(5):791-802. doi:10.1083/jcb.200606017
apa: Witzel, S., Zimyanin, V., Carreira Barbosa, F., Tada, M., & Heisenberg,
C.-P. J. (2006). Wnt11 controls cell contact persistence by local accumulation
of Frizzled 7 at the plasma membrane. Journal of Cell Biology. Rockefeller
University Press. https://doi.org/10.1083/jcb.200606017
chicago: Witzel, Sabine, Vitaly Zimyanin, Filipa Carreira Barbosa, Masazumi Tada,
and Carl-Philipp J Heisenberg. “Wnt11 Controls Cell Contact Persistence by Local
Accumulation of Frizzled 7 at the Plasma Membrane.” Journal of Cell Biology.
Rockefeller University Press, 2006. https://doi.org/10.1083/jcb.200606017.
ieee: S. Witzel, V. Zimyanin, F. Carreira Barbosa, M. Tada, and C.-P. J. Heisenberg,
“Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at
the plasma membrane,” Journal of Cell Biology, vol. 175, no. 5. Rockefeller
University Press, pp. 791–802, 2006.
ista: Witzel S, Zimyanin V, Carreira Barbosa F, Tada M, Heisenberg C-PJ. 2006. Wnt11
controls cell contact persistence by local accumulation of Frizzled 7 at the plasma
membrane. Journal of Cell Biology. 175(5), 791–802.
mla: Witzel, Sabine, et al. “Wnt11 Controls Cell Contact Persistence by Local Accumulation
of Frizzled 7 at the Plasma Membrane.” Journal of Cell Biology, vol. 175,
no. 5, Rockefeller University Press, 2006, pp. 791–802, doi:10.1083/jcb.200606017.
short: S. Witzel, V. Zimyanin, F. Carreira Barbosa, M. Tada, C.-P.J. Heisenberg,
Journal of Cell Biology 175 (2006) 791–802.
date_created: 2018-12-11T12:07:11Z
date_published: 2006-12-04T00:00:00Z
date_updated: 2021-01-12T07:54:48Z
day: '04'
doi: 10.1083/jcb.200606017
extern: '1'
intvolume: ' 175'
issue: '5'
language:
- iso: eng
month: '12'
oa_version: None
page: 791 - 802
publication: Journal of Cell Biology
publication_status: published
publisher: Rockefeller University Press
publist_id: '1980'
status: public
title: Wnt11 controls cell contact persistence by local accumulation of Frizzled 7
at the plasma membrane
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 175
year: '2006'
...