{"month":"09","status":"public","publist_id":"2166","type":"journal_article","page":"744 - 750","citation":{"apa":"Renkawitz, J., &#38; Sixt, M. K. (2010). Mechanisms of force generation and force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/embor.2010.147\">https://doi.org/10.1038/embor.2010.147</a>","short":"J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750.","chicago":"Renkawitz, Jörg, and Michael K Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>. Wiley-Blackwell, 2010. <a href=\"https://doi.org/10.1038/embor.2010.147\">https://doi.org/10.1038/embor.2010.147</a>.","ieee":"J. Renkawitz and M. K. Sixt, “Mechanisms of force generation and force transmission during interstitial leukocyte migration,” <i>EMBO Reports</i>, vol. 11, no. 10. Wiley-Blackwell, pp. 744–750, 2010.","mla":"Renkawitz, Jörg, and Michael K. Sixt. “Mechanisms of Force Generation and Force Transmission during Interstitial Leukocyte Migration.” <i>EMBO Reports</i>, vol. 11, no. 10, Wiley-Blackwell, 2010, pp. 744–50, doi:<a href=\"https://doi.org/10.1038/embor.2010.147\">10.1038/embor.2010.147</a>.","ista":"Renkawitz J, Sixt MK. 2010. Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Reports. 11(10), 744–750.","ama":"Renkawitz J, Sixt MK. Mechanisms of force generation and force transmission during interstitial leukocyte migration. <i>EMBO Reports</i>. 2010;11(10):744-750. doi:<a href=\"https://doi.org/10.1038/embor.2010.147\">10.1038/embor.2010.147</a>"},"acknowledgement":"We are grateful to Michele Weber for critical comments on the manuscript. Work in the laboratory of M.S. is supported by the German Research Foundation, the Peter Hans Hofschneider Foundation for Experimental Biomedicine and the Max Planck Society. J.R. is supported by a PhD fellowship of the Böhringer Ingelheim Fond. We thank Reinhard Fässler and Stefan Jentsch for their continuous support.","volume":11,"publication":"EMBO Reports","year":"2010","date_created":"2018-12-11T12:06:08Z","issue":"10","date_published":"2010-09-24T00:00:00Z","date_updated":"2021-01-12T07:53:30Z","extern":1,"_id":"3961","abstract":[{"text":"For innate and adaptive immune responses it is essential that inflammatory cells use quick and flexible locomotion strategies. Accordingly, most leukocytes can efficiently infiltrate and traverse almost every physiological or artificial environment. Here, we review how leukocytes might achieve this task mechanistically, and summarize recent findings on the principles of cytoskeletal force generation and transduction at the leading edge of leukocytes. We propose a model in which the cells switch between adhesion-receptor-mediated force transmission and locomotion modes that are based on cellular deformations, but independent of adhesion receptors. This plasticity in migration strategies allows leukocytes to adapt to the geometry and molecular composition of their environment.","lang":"eng"}],"quality_controlled":0,"intvolume":"        11","title":"Mechanisms of force generation and force transmission during interstitial leukocyte migration","publisher":"Wiley-Blackwell","doi":"10.1038/embor.2010.147","author":[{"first_name":"Jörg","full_name":"Jörg Renkawitz","orcid":"0000-0003-2856-3369","last_name":"Renkawitz","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Michael K","full_name":"Michael Sixt","orcid":"0000-0002-6620-9179","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"day":"24","publication_status":"published"}