MEK signalling tunes actin treadmilling for interstitial lymphocyte migration

Weber M, Sixt MK. 2010. MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. EMBO Journal. 29(17), 2861–2863.


Journal Article | Published
Abstract
When lymphocytes follow chemotactic cues, they can adopt different migratory modes depending on the geometry and molecular composition of their extracellular environment. In this issue of The EMBO Journal, Klemke et al (2010) describe a novel Ras-dependent chemokine receptor signalling pathway that leads to activation of cofilin, which in turn amplifies actin turnover. This signalling module is exclusively required for lymphocyte migration in three-dimensional (3D) environments, but not for locomotion on two-dimensional (2D) surfaces.
Publishing Year
Date Published
2010-09-01
Journal Title
EMBO Journal
Volume
29
Issue
17
Page
2861 - 2863
IST-REx-ID

Cite this

Weber M, Sixt MK. MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. EMBO Journal. 2010;29(17):2861-2863. doi:10.1038/emboj.2010.183
Weber, M., & Sixt, M. K. (2010). MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1038/emboj.2010.183
Weber, Michele, and Michael K Sixt. “MEK Signalling Tunes Actin Treadmilling for Interstitial Lymphocyte Migration.” EMBO Journal. Wiley-Blackwell, 2010. https://doi.org/10.1038/emboj.2010.183.
M. Weber and M. K. Sixt, “MEK signalling tunes actin treadmilling for interstitial lymphocyte migration,” EMBO Journal, vol. 29, no. 17. Wiley-Blackwell, pp. 2861–2863, 2010.
Weber M, Sixt MK. 2010. MEK signalling tunes actin treadmilling for interstitial lymphocyte migration. EMBO Journal. 29(17), 2861–2863.
Weber, Michele, and Michael K. Sixt. “MEK Signalling Tunes Actin Treadmilling for Interstitial Lymphocyte Migration.” EMBO Journal, vol. 29, no. 17, Wiley-Blackwell, 2010, pp. 2861–63, doi:10.1038/emboj.2010.183.
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