Mechanical modes of 'amoeboid' cell migration

Lämmermann T, Sixt MK. 2009. Mechanical modes of ‘amoeboid’ cell migration. Current Opinion in Cell Biology. 21(5), 636–644.

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Journal Article | Published
Author
Lämmermann, Tim; Sixt, Michael KIST Austria
Abstract
The morphological term 'amoeboid' migration subsumes a number of rather distinct biophysical modes of cellular locomotion that range from blebbing motility to entirely actin-polymerization-based gliding. Here, we discuss the diverse principles of force generation and force transduction that lead to the distinct amoeboid phenotypes. We argue that shifting the balance between actin protrusion, actomyosin contraction, and adhesion to the extracellular substrate can explain the different modes of amoeboid movement and that blebbing and gliding are barely extreme variants of one common migration strategy. Depending on the cell type, physiological conditions or experimental manipulation, amoeboid cells can adopt the distinct mechanical modes of amoeboid migration.
Publishing Year
Date Published
2009-10-01
Journal Title
Current Opinion in Cell Biology
Volume
21
Issue
5
Page
636 - 644
IST-REx-ID

Cite this

Lämmermann T, Sixt MK. Mechanical modes of “amoeboid” cell migration. Current Opinion in Cell Biology. 2009;21(5):636-644. doi:10.1016/j.ceb.2009.05.003
Lämmermann, T., & Sixt, M. K. (2009). Mechanical modes of “amoeboid” cell migration. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2009.05.003
Lämmermann, Tim, and Michael K Sixt. “Mechanical Modes of ‘amoeboid’ Cell Migration.” Current Opinion in Cell Biology. Elsevier, 2009. https://doi.org/10.1016/j.ceb.2009.05.003.
T. Lämmermann and M. K. Sixt, “Mechanical modes of ‘amoeboid’ cell migration,” Current Opinion in Cell Biology, vol. 21, no. 5. Elsevier, pp. 636–644, 2009.
Lämmermann T, Sixt MK. 2009. Mechanical modes of ‘amoeboid’ cell migration. Current Opinion in Cell Biology. 21(5), 636–644.
Lämmermann, Tim, and Michael K. Sixt. “Mechanical Modes of ‘amoeboid’ Cell Migration.” Current Opinion in Cell Biology, vol. 21, no. 5, Elsevier, 2009, pp. 636–44, doi:10.1016/j.ceb.2009.05.003.

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