Rapid leukocyte migration by integrin-independent flowing and squeezing

Lämmermann T, Bader B, Monkley S, Worbs T, Wedlich Söldner R, Hirsch K, Keller M, Förster R, Critchley D, Fässler R, Sixt MK. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 453(7191), 51–55.

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Journal Article | Published
Author
Lämmermann, Tim; Bader, Bernhard L; Monkley, Susan J; Worbs, Tim; Wedlich-Söldner, Roland; Hirsch, Karin; Keller, Markus; Förster, Reinhold; Critchley, David R; Fässler, Reinhard; Chatterjee, KrishnenduIST Austria
Abstract
All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment. In agreement with this principle, rapidly migrating leukocytes use integrin-mediated adhesion when moving over two-dimensional surfaces. As migration on two-dimensional substrates naturally overemphasizes the role of adhesion, the contribution of integrins during three-dimensional movement of leukocytes within tissues has remained controversial. We studied the interplay between adhesive, contractile and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro. We ablated all integrin heterodimers from murine leukocytes, and show here that functional integrins do not contribute to migration in three-dimensional environments. Instead, these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge. Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus.
Publishing Year
Date Published
2008-05-01
Journal Title
Nature
Volume
453
Issue
7191
Page
51 - 55
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Lämmermann T, Bader B, Monkley S, et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008;453(7191):51-55. doi:10.1038/nature06887
Lämmermann, T., Bader, B., Monkley, S., Worbs, T., Wedlich Söldner, R., Hirsch, K., … Sixt, M. K. (2008). Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. Nature Publishing Group. https://doi.org/10.1038/nature06887
Lämmermann, Tim, Bernhard Bader, Susan Monkley, Tim Worbs, Roland Wedlich Söldner, Karin Hirsch, Markus Keller, et al. “Rapid Leukocyte Migration by Integrin-Independent Flowing and Squeezing.” Nature. Nature Publishing Group, 2008. https://doi.org/10.1038/nature06887.
T. Lämmermann et al., “Rapid leukocyte migration by integrin-independent flowing and squeezing,” Nature, vol. 453, no. 7191. Nature Publishing Group, pp. 51–55, 2008.
Lämmermann T, Bader B, Monkley S, Worbs T, Wedlich Söldner R, Hirsch K, Keller M, Förster R, Critchley D, Fässler R, Sixt MK. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 453(7191), 51–55.
Lämmermann, Tim, et al. “Rapid Leukocyte Migration by Integrin-Independent Flowing and Squeezing.” Nature, vol. 453, no. 7191, Nature Publishing Group, 2008, pp. 51–55, doi:10.1038/nature06887.

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