Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons

H. Hu, M. Martina, P.M. Jonas, Science 327 (2010) 52–8.

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Abstract
Fast-spiking, parvalbumin-expressing basket cells (BCs) are important for feedforward and feedback inhibition. During network activity, BCs respond with short latency and high temporal precision. It is thought that the specific properties of input synapses are responsible for rapid recruitment. However, a potential contribution of active dendritic conductances has not been addressed. We combined confocal imaging and patch-clamp techniques to obtain simultaneous somatodendritic recordings from BCs. Action potentials were initiated in the BC axon and backpropagated into the dendrites with reduced amplitude and little activity dependence. These properties were explained by a high K+ to Na+ conductance ratio in BC dendrites. Computational analysis indicated that dendritic K+ channels convey unique integration properties to BCs, leading to the rapid and temporally precise activation by excitatory inputs.
Publishing Year
Date Published
2010-01-01
Journal Title
Science
Volume
327
Issue
5961
Page
52 - 8
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Hu H, Martina M, Jonas PM. Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons. Science. 2010;327(5961):52-58. doi:10.1126/science.1177876
Hu, H., Martina, M., & Jonas, P. M. (2010). Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons. Science, 327(5961), 52–58. https://doi.org/10.1126/science.1177876
Hu, Hua, Marco Martina, and Peter M Jonas. “Dendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons.” Science 327, no. 5961 (2010): 52–58. https://doi.org/10.1126/science.1177876.
H. Hu, M. Martina, and P. M. Jonas, “Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons,” Science, vol. 327, no. 5961, pp. 52–8, 2010.
Hu H, Martina M, Jonas PM. 2010. Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal interneurons. Science. 327(5961), 52–8.
Hu, Hua, et al. “Dendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons.” Science, vol. 327, no. 5961, American Association for the Advancement of Science, 2010, pp. 52–58, doi:10.1126/science.1177876.

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