Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

J. Schwenk, N. Harmel, G. Zolles, W. Bildl, Á. Kulik, B. Heimrich, O. Chisaka, P.M. Jonas, U. Schulte, B. Fakler, N. Klocker, Science 323 (2009) 1313–9.

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Abstract
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with cornichon homologs 2 and 3 affects AMPARs in two ways: Cornichons increase surface expression of AMPARs, and they alter channel gating by markedly slowing deactivation and desensitization kinetics. These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system.
Publishing Year
Date Published
2009-01-01
Journal Title
Science
Volume
323
Issue
5919
Page
1313 - 9
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Schwenk J, Harmel N, Zolles G, et al. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science. 2009;323(5919):1313-1319. doi:10.1126/science.1167852
Schwenk, J., Harmel, N., Zolles, G., Bildl, W., Kulik, Á., Heimrich, B., … Klocker, N. (2009). Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science, 323(5919), 1313–1319. https://doi.org/10.1126/science.1167852
Schwenk, Jochen, Nadine Harmel, Gerd Zolles, Wolfgang Bildl, Ákos Kulik, Bernd Heimrich, Osamu Chisaka, et al. “Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors.” Science 323, no. 5919 (2009): 1313–19. https://doi.org/10.1126/science.1167852.
J. Schwenk et al., “Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors,” Science, vol. 323, no. 5919, pp. 1313–9, 2009.
Schwenk J, Harmel N, Zolles G, Bildl W, Kulik Á, Heimrich B, Chisaka O, Jonas PM, Schulte U, Fakler B, Klocker N. 2009. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science. 323(5919), 1313–9.
Schwenk, Jochen, et al. “Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors.” Science, vol. 323, no. 5919, American Association for the Advancement of Science, 2009, pp. 1313–19, doi:10.1126/science.1167852.

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