Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review)

S. Hefft, P.M. Jonas, Nature Neuroscience 8 (2005) 1319–28.

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Abstract
Hippocampal GABAergic interneurons show diverse molecular and morphological properties. The functional significance of this diversity for information processing is poorly understood. Here we show that cholecystokinin (CCK)-expressing interneurons in rat dentate gyrus release GABA in a highly asynchronous manner, in contrast to parvalbumin (PV) interneurons. With a gamma-frequency burst of ten action potentials, the ratio of asynchronous to synchronous release is 3:1 in CCK interneurons but is 1:5 in parvalbumin interneurons. N-type channels trigger synchronous and asynchronous release in CCK interneuron synapses, whereas P/Q-type Ca(2+) channels mediate release at PV interneuron synapses. Effects of Ca(2+) chelators suggest that both a long-lasting presynaptic Ca(2+) transient and a large distance between Ca(2+) source and sensor of exocytosis contribute to the higher ratio of asynchronous to synchronous release in CCK interneuron synapses. Asynchronous release occurs at physiological temperature and with behaviorally relevant stimulation patterns, thus generating long-lasting inhibition in the brain.
Publishing Year
Date Published
2005-01-01
Journal Title
Nature Neuroscience
Volume
8
Issue
10
Page
1319 - 28
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Hefft S, Jonas PM. Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). Nature Neuroscience. 2005;8(10):1319-1328. doi:10.1038/nn1542
Hefft, S., & Jonas, P. M. (2005). Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn1542
Hefft, Stefan, and Peter M Jonas. “Asynchronous GABA Release Generates Long-Lasting Inhibition at a Hippocampal Interneuron-Principal Neuron Synapse (Review).” Nature Neuroscience. Nature Publishing Group, 2005. https://doi.org/10.1038/nn1542.
S. Hefft and P. M. Jonas, “Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review),” Nature Neuroscience, vol. 8, no. 10. Nature Publishing Group, pp. 1319–28, 2005.
Hefft S, Jonas PM. 2005. Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse (Review). Nature Neuroscience. 8(10), 1319–28.
Hefft, Stefan, and Peter M. Jonas. “Asynchronous GABA Release Generates Long-Lasting Inhibition at a Hippocampal Interneuron-Principal Neuron Synapse (Review).” Nature Neuroscience, vol. 8, no. 10, Nature Publishing Group, 2005, pp. 1319–28, doi:10.1038/nn1542.

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