Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids

D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P.M. Jonas, B. Fakler, Science 304 (2004) 265–70.

Download
No fulltext has been uploaded. References only!

Journal Article | Published
Author
; ; ; ; ;
Abstract
Voltage-gated potassium (Kv) channels control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells. It is thought that the combinatorial association between distinct alpha and beta subunits determines whether Kv channels function as non-inactivating delayed rectifiers or as rapidly inactivating A-type channels. We show that membrane lipids can convert A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove N-type inactivation from A-type channels by immobilizing the inactivation domains. Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers with rapid voltage-dependent inactivation. The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system.
Publishing Year
Date Published
2004-01-01
Journal Title
Science
Volume
304
Issue
5668
Page
265 - 70
IST-REx-ID

Cite this

Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 2004;304(5668):265-270. doi:10.1126/science.1094113
Oliver, D., Lien, C., Soom, M., Baukrowitz, T., Jonas, P. M., & Fakler, B. (2004). Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science, 304(5668), 265–270. https://doi.org/10.1126/science.1094113
Oliver, Dominik, Cheng Lien, Malle Soom, Thomas Baukrowitz, Peter M Jonas, and Bernd Fakler. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” Science 304, no. 5668 (2004): 265–70. https://doi.org/10.1126/science.1094113.
D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P. M. Jonas, and B. Fakler, “Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids,” Science, vol. 304, no. 5668, pp. 265–70, 2004.
Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. 2004. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 304(5668), 265–70.
Oliver, Dominik, et al. “Functional Conversion between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids.” Science, vol. 304, no. 5668, American Association for the Advancement of Science, 2004, pp. 265–70, doi:10.1126/science.1094113.

Export

Marked Publications

Open Data IST Research Explorer

Search this title in

Google Scholar