Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons

D. Engel, P.M. Jonas, Neuron 45 (2005) 405–17.

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Journal Article | Published
Author
Engel, Dominique; Jonas, Peter MIST Austria
Abstract
Action potentials in central neurons are initiated near the axon initial segment, propagate into the axon, and finally invade the presynaptic terminals, where they trigger transmitter release. Voltage-gated Na(+) channels are key determinants of excitability, but Na(+) channel density and properties in axons and presynaptic terminals of cortical neurons have not been examined yet. In hippocampal mossy fiber boutons, which emerge from parent axons en passant, Na(+) channels are very abundant, with an estimated number of approximately 2000 channels per bouton. Presynaptic Na(+) channels show faster inactivation kinetics than somatic channels, suggesting differences between subcellular compartments of the same cell. Computational analysis of action potential propagation in axon-multibouton structures reveals that Na(+) channels in boutons preferentially amplify the presynaptic action potential and enhance Ca(2+) inflow, whereas Na(+) channels in axons control the reliability and speed of propagation. Thus, presynaptic and axonal Na(+) channels contribute differentially to mossy fiber synaptic transmission.
Publishing Year
Date Published
2005-01-01
Journal Title
Neuron
Volume
45
Issue
3
Page
405 - 17
IST-REx-ID

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Engel D, Jonas PM. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. 2005;45(3):405-417. doi:10.1016/j.neuron.2004.12.048
Engel, D., & Jonas, P. M. (2005). Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron, 45(3), 405–417. https://doi.org/10.1016/j.neuron.2004.12.048
Engel, Dominique, and Peter M Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron 45, no. 3 (2005): 405–17. https://doi.org/10.1016/j.neuron.2004.12.048 .
D. Engel and P. M. Jonas, “Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 45, no. 3, pp. 405–17, 2005.
Engel D, Jonas PM. 2005. Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron. 45(3), 405–17.
Engel, Dominique, and Peter M. Jonas. “Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron, vol. 45, no. 3, Elsevier, 2005, pp. 405–17, doi:10.1016/j.neuron.2004.12.048 .

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